G B Huffnagle
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Explore the profile of G B Huffnagle including associated specialties, affiliations and a list of published articles.
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42
Citations
2233
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Recent Articles
1.
Lipinski J, Zhou X, Gurczynski S, Erb-Downward J, Dickson R, Huffnagle G, et al.
Infect Immun
. 2021 May;
89(9):e0018721.
PMID: 33941577
The gut microbiome orchestrates epithelial homeostasis and both local and remote immunological responses. Critical to these regulatory interactions are innate immune receptors termed Toll-like receptors (TLRs). Studies to date have...
2.
Huffnagle G, Dickson R, Lukacs N
Mucosal Immunol
. 2016 Dec;
10(2):299-306.
PMID: 27966551
The lungs are not sterile or free from bacteria; rather, they harbor a distinct microbiome whose composition is driven by different ecological rules than for the gastrointestinal tract. During disease,...
3.
Noverr M, Huffnagle G
Clin Exp Allergy
. 2006 Jan;
35(12):1511-20.
PMID: 16393316
Increasingly, epidemiologic and clinical data support the hypothesis that perturbations in the gastrointestinal (GI) microbiota because of antibiotic use and dietary differences in 'industrialized' countries have disrupted the normal microbiota-mediated...
4.
Lindell D, Standiford T, Mancuso P, Leshen Z, Huffnagle G
Infect Immun
. 2001 Sep;
69(10):6364-9.
PMID: 11553580
The objective of these studies was to determine the role of macrophage inflammatory protein 1alpha/CCL3 in pulmonary host defense during Klebsiella pneumoniae infection. Following intratracheal inoculation, 7-day survival of CCL3(-/-)...
5.
Olszewski M, Huffnagle G, Traynor T, McDonald R, Cook D, Toews G
Infect Immun
. 2001 Sep;
69(10):6256-63.
PMID: 11553568
Macrophage inflammatory protein 1alpha (MIP-1alpha)/CCL3 prevents the development of eosinophilic pneumonia (EP) driven by a nonprotective T2-type immunity during infection with a highly virulent strain of Cryptococcus neoformans. The present...
6.
Noverr M, Phare S, Toews G, Coffey M, Huffnagle G
Infect Immun
. 2001 Apr;
69(5):2957-63.
PMID: 11292712
Enhanced prostaglandin production during fungal infection could be an important factor in promoting fungal colonization and chronic infection. Host cells are one source of prostaglandins; however, another potential source of...
7.
Traynor T, Huffnagle G
Med Mycol
. 2001 Mar;
39(1):41-50.
PMID: 11270407
The production of chemokines at the site of a fungal infection is critical for effective recruitment of leukocytes to that site. Over 40 chemokines and 20 chemokine receptors have been...
8.
Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle G, et al.
Nat Immunol
. 2001 Mar;
1(1):83-7.
PMID: 10881180
The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show...
9.
Olszewski M, Huffnagle G, McDonald R, Lindell D, Moore B, Cook D, et al.
J Immunol
. 2000 Nov;
165(11):6429-36.
PMID: 11086082
Macrophage inflammatory protein-1alpha (MIP-1alpha/CCL3) is a CC chemokine required for optimal recruitment of leukocytes in response to cryptococcal Ags. MIP-1alpha is expressed in the lungs by day 6 post Cryptococcus...
10.
Fife B, Huffnagle G, Kuziel W, Karpus W
J Exp Med
. 2000 Sep;
192(6):899-905.
PMID: 10993920
Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T lymphocyte-mediated disease of the central nervous system (CNS) characterized by mononuclear cell infiltration, demyelination, and paralysis. We previously demonstrated a role for...