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G Andrei

Explore the profile of G Andrei including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 139
Citations 1129
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
R Snoeck
E De Clercq
J Balzarini
C McGuigan
J Neyts
M Witvrouw
D Schols
A Carangio
S Ikeda
A Holy
Published In
J Med Chem
Nucleosides Nucleotides Nucleic Acids
Antimicrob Agents Chemother
Antiviral Res
Antivir Chem Chemother
Affiliations
Soon will be listed here.
Recent Articles
1.
Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus Replication
Paramonova M, Gureeva E, Ozerov A, Snoeck R, Andrei G, Aleksandrov D, et al.
Dokl Biochem Biophys . 2023 Jun; 509(1):41-46. PMID: 37340290
The synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene 9-methyl fragment was carried out. The antiviral properties of the synthesized...
2.
Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
Paramonova M, Gureeva E, Ozerov A, Snoeck R, Andrei G, Alexandrov D, et al.
Dokl Biochem Biophys . 2023 Feb; 507(1):357-362. PMID: 36787002
A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl fragments in position 3 of uracil residue was synthesized. The antiviral properties of the synthesized compounds against...
3.
[Novel therapeutic weapons against poxviruses]
Duraffour S, Andrei G, Snoeck R
Virologie (Montrouge) . 2022 Sep; 12(5):323-338. PMID: 36151678
Poxviruses include several pathogens responsible for diseases recognized as important for human health, such as smallpox, monkeypox, orf and molluscum contagiosum. Smallpox, whose etiological agent is Variola virus, is a...
4.
Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives
Paramonova M, Khandazhinskaya A, Ozerov A, Kochetkov S, Snoeck R, Andrei G, et al.
Acta Naturae . 2020 Nov; 12(3):134-139. PMID: 33173603
A series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for new...
5.
Lymphocyte-independent pathways underlie the pathogenesis of murine cytomegalovirus-associated secondary haemophagocytic lymphohistiocytosis
Brisse E, Imbrechts M, Mitera T, Vandenhaute J, Berghmans N, Boon L, et al.
Clin Exp Immunol . 2017 Nov; 192(1):104-119. PMID: 29178470
Haemophagocytic lymphohistiocytosis (HLH) constitutes a spectrum of immunological disorders characterized by uncontrolled immune activation and key symptoms such as fever, splenomegaly, pancytopenia, haemophagocytosis, hyperferritinaemia and hepatitis. In genetic or primary...
6.
Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase
Topalis D, Gillemot S, Snoeck R, Andrei G
Nucleic Acids Res . 2016 Oct; 44(20):9530-9554. PMID: 27694307
Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is currently the target of nucleos(t)ide analogue-based therapy. Mutations in DNApol...
7.
2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
Babkov D, Paramonova M, Ozerov A, Khandazhinskaya A, Snoeck R, Andrei G, et al.
Acta Naturae . 2016 Jan; 7(4):142-5. PMID: 26798502
A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the...
8.
Insights into the mechanism of action of cidofovir and other acyclic nucleoside phosphonates against polyoma- and papillomaviruses and non-viral induced neoplasia
Andrei G, Topalis D, De Schutter T, Snoeck R
Antiviral Res . 2014 Dec; 114:21-46. PMID: 25446403
Acyclic nucleoside phosphonates (ANPs) are well-known for their antiviral properties, three of them being approved for the treatment of human immunodeficiency virus infection (tenofovir), chronic hepatitis B (tenofovir and adefovir)...
9.
Advances in the treatment of varicella-zoster virus infections
Andrei G, Snoeck R
Adv Pharmacol . 2013 Jul; 67:107-68. PMID: 23886000
Varicella-zoster virus (VZV) causes two distinct diseases, varicella (chickenpox) and shingles (herpes zoster). Chickenpox occurs subsequent to primary infection, while herpes zoster (usually associated with aging and immunosuppression) appears as...
10.
Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses
Coen N, Singh U, Vuyyuru V, van den Oord J, Balzarini J, Duraffour S, et al.
J Virol . 2013 Jan; 87(7):3839-51. PMID: 23345517
A novel nucleoside analogue, 1-[(2S,4S-2-(hydroxymethyl)-1,3-dioxolan-4-yl]5-vinylpyrimidine-2,4(1H,3H)-dione, or HDVD, was evaluated against a wide variety of herpesviruses and was found to be a highly selective inhibitor of replication of the gammaherpesviruses Kaposi's...