G Akk
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Explore the profile of G Akk including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
1.
Teitelbaum A, Murphy S, Akk G, Baker T, Germann A, von Weymarn L, et al.
Pharmacogenomics J
. 2017 Mar;
18(1):136-143.
PMID: 28290528
A common haplotype of the flavin-containing monooxygenase gene FMO3 is associated with aberrant mRNA splicing, a twofold reduction in in vivo nicotine N-oxidation and reduced nicotine dependence. Tobacco remains the...
2.
Li P, Bracamontes J, Manion B, Mennerick S, Steinbach J, Evers A, et al.
Br J Pharmacol
. 2014 Aug;
171(23):5446-57.
PMID: 25117207
Background And Purpose: Neurosteroids potentiate responses of the GABAA receptor to the endogenous agonist GABA. Here, we examined the ability of neurosteroids to potentiate responses to the allosteric activators etomidate,...
3.
Li P, Akk G
Br J Pharmacol
. 2008 Jul;
155(5):783-94.
PMID: 18660823
Background And Purpose: Fipronil is the active ingredient in a number of widely used insecticides. Human exposure to fipronil leads to symptoms (headache, nausea and seizures) typically associated with the...
4.
Akk G, Mennerick S, Steinbach J
Handb Exp Pharmacol
. 2008 Jan;
(182):53-84.
PMID: 18175086
Excitatory transmitter-gated receptors are found in three gene families: the glutamate ionotropic receptors, the Cys-loop receptor family (nicotinic and 5HT3), and the purinergic (P2X) receptors. Anesthetic drugs act on many...
5.
Li P, Reichert D, Rodriguez A, Manion B, Evers A, Eterovic V, et al.
Br J Pharmacol
. 2007 Nov;
153(3):598-608.
PMID: 18037909
Background And Purpose: Eupalmerin acetate (EPA) is a marine diterpene compound isolated from the gorgonian octocorals Eunicea succinea and Eunicea mammosa. The compound has been previously shown to modulate muscle-type...
6.
Ulrich H, Akk G, Nery A, Trujillo C, Rodriguez A, Eterovic V
J Neurosci Res
. 2007 Sep;
86(1):93-107.
PMID: 17868151
The mechanism of eupalmerin acetate (EUAC) actions on the embryonic muscle nicotinic acetylcholine receptor (nAChR) in BC3H-1 cells was studied by using whole-cell and single-channel patch-clamp current measurements. With whole-cell...
7.
Steinbach J, Akk G
J Physiol
. 2001 Dec;
537(Pt 3):715-33.
PMID: 11744750
1. We have studied the kinetic properties of channel gating of recombinant alpha 1 beta 2 gamma 2L GABA(A) receptors transiently expressed in human embryonic kidney 293 cells, using the...
8.
Browne S, Kang J, Akk G, Chiang L, Schulman H, Huguenard J, et al.
J Neurophysiol
. 2001 Nov;
86(5):2312-22.
PMID: 11698521
Synaptic inhibition in the thalamus plays critical roles in sensory processing and thalamocortical rhythm generation. To determine kinetic, pharmacological, and structural properties of thalamic gamma-aminobutyric acid type A (GABA(A)) receptors,...
9.
Akk G
J Physiol
. 2001 Sep;
535(Pt 3):729-40.
PMID: 11559771
1. Two aromatic residues of the muscle nicotinic receptor putative agonist binding site, a tyrosine in position alpha93 and a tryptophan in position alpha149, were mutated to phenylalanine and the...
10.
Akk G, Bracamontes J, Steinbach J
J Physiol
. 2001 Apr;
532(Pt 3):673-84.
PMID: 11313438
Neurosteroids are produced in the brain, and can have rapid actions on membrane channels of neurons. Pregnenolone sulfate (PS) is a sulfated neurosteroid which reduces the responses of the [gamma]-aminobutyric...