Fuminori Tsuruta
Overview
Explore the profile of Fuminori Tsuruta including associated specialties, affiliations and a list of published articles.
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36
Citations
1080
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Recent Articles
21.
Tsuruta F, Takebe A, Haratake K, Kanemori Y, Kim J, Endo T, et al.
Mol Cell Biol
. 2016 May;
36(16):2182-94.
PMID: 27215384
The cyclin-dependent kinase (CDK) inhibitor p21 is an unstructured protein regulated by multiple turnover pathways. p21 abundance is tightly regulated, and its defect causes tumor development. However, the mechanisms that...
22.
23.
Haratake K, Sato A, Tsuruta F, Chiba T
J Biochem
. 2016 Jan;
159(6):609-18.
PMID: 26802743
Many cellular stresses cause damages of intracellular proteins, which are eventually degraded by the ubiquitin and proteasome system. The proteasome is a multicatalytic protease complex composed of 20S core particle...
24.
Kigoshi Y, Fukuda T, Endo T, Hayasaka N, Iemura S, Natsume T, et al.
Sci Rep
. 2015 Aug;
5:12857.
PMID: 26238671
Nrf2 is the pre-dominant transcription activator responsible for coordinated up-regulation of ARE-driven antioxidant and detoxification genes. The activity of Nrf2 is tightly regulated at basal levels through its ubiquitination by...
25.
Tsuruta F, Dolmetsch R
Neurosci Lett
. 2015 Aug;
605:18-23.
PMID: 26232680
The endosome/lysosome system in the nervous system is critically important for a variety of neuronal functions such as neurite outgrowth, retrograde transport, and synaptic plasticity. In neurons, the endosome/lysosome system...
26.
Ebina M, Tsuruta F, Katoh M, Kigoshi Y, Someya A, Chiba T
PLoS One
. 2013 Jun;
8(6):e65285.
PMID: 23776465
Nucleolus is a dynamic structure that controls biogenesis of ribosomal RNA and senses cellular stresses. Nucleolus contains a number of proteins including ribosomal proteins that conduct cellular stresses to downstream...
27.
Qian M, Pang Y, Liu C, Haratake K, Du B, Ji D, et al.
Cell
. 2013 May;
153(5):1012-24.
PMID: 23706739
Histone acetylation plays critical roles in chromatin remodeling, DNA repair, and epigenetic regulation of gene expression, but the underlying mechanisms are unclear. Proteasomes usually catalyze ATP- and polyubiquitin-dependent proteolysis. Here,...
28.
Hall D, Dai S, Tseng P, Malik Z, Nguyen M, Matt L, et al.
Neuron
. 2013 May;
78(3):483-97.
PMID: 23664615
Regulation of neuronal excitability and cardiac excitation-contraction coupling requires the proper localization of L-type Ca²⁺ channels. We show that the actin-binding protein α-actinin binds to the C-terminal surface targeting motif...
29.
Takashima O, Tsuruta F, Kigoshi Y, Nakamura S, Kim J, Katoh M, et al.
PLoS One
. 2013 Apr;
8(3):e58911.
PMID: 23554956
Nuclear factor-kappaB (NF-κB) is critical for the expression of multiple genes involved in inflammatory responses and cellular survival. NF-κB is normally sequestered in the cytoplasm through interaction with an inhibitor...
30.
Takahashi M, Obayashi M, Ishiguro T, Sato N, Niimi Y, Ozaki K, et al.
PLoS One
. 2013 Mar;
8(3):e50121.
PMID: 23505410
The human α1A voltage-dependent calcium channel (Cav2.1) is a pore-forming essential subunit embedded in the plasma membrane. Its cytoplasmic carboxyl(C)-tail contains a small poly-glutamine (Q) tract, whose length is normally...