FuJung Chang
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Explore the profile of FuJung Chang including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
272
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Recent Articles
1.
Hoggard T, Chang F, Perry K, Subramanian S, Kenworthy J, Chueng J, et al.
PLoS Genet
. 2018 May;
14(5):e1007418.
PMID: 29795547
Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone...
2.
Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, et al.
Elife
. 2015 Aug;
4.
PMID: 26305410
To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly. The essential...
3.
Hiraga S, Alvino G, Chang F, Lian H, Sridhar A, Kubota T, et al.
Genes Dev
. 2014 Feb;
28(4):372-83.
PMID: 24532715
Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of Cdc7 kinase and its activator, Dbf4. We report here that budding yeast Rif1...
4.
Chang F, May C, Hoggard T, Miller J, Fox C, Weinreich M
Nucleic Acids Res
. 2011 May;
39(15):6523-35.
PMID: 21558171
In budding yeast, the eukaryotic initiator protein ORC (origin recognition complex) binds to a bipartite sequence consisting of an 11 bp ACS element and an adjacent B1 element. However, the...
5.
Chang F, Theis J, Miller J, Nieduszynski C, Newlon C, Weinreich M
Mol Cell Biol
. 2008 Jun;
28(16):5071-81.
PMID: 18573888
Saccharomyces cerevisiae chromosome III encodes 11 autonomously replicating sequence (ARS) elements that function as chromosomal replicators. The essential 11-bp ARS consensus sequence (ACS) that binds the origin recognition complex (ORC)...
6.
Crampton A, Chang F, Pappas Jr D, Frisch R, Weinreich M
Mol Cell
. 2008 Apr;
30(2):156-66.
PMID: 18439895
During G1 phase, a prereplicative complex (pre-RC) that determines where DNA synthesis initiates forms at origins. The Sir2p histone deacetylase inhibits pre-RC assembly at a subset of origins, suggesting that...