Frederick G Hamel
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Explore the profile of Frederick G Hamel including associated specialties, affiliations and a list of published articles.
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26
Citations
373
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Recent Articles
1.
McVicker B, Simpson R, Hamel F, Bennett R
Biology (Basel)
. 2023 Oct;
12(10).
PMID: 37886997
Peroxisome-proliferator-activated receptor gamma (PPARγ) is a transcription factor with adipogenic, insulin-sensitizing, and antifibrotic properties. Strong PPARγ activators, such as the thiazolidinediones, can induce unwanted effects such as edema, weight gain,...
2.
McVicker B, Hamel F, Simpson R, Bennett R
Biology (Basel)
. 2020 Jul;
9(7).
PMID: 32630819
Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal...
3.
Bennett R, Simpson R, Hamel F
World J Gastroenterol
. 2017 Jun;
23(22):3999-4006.
PMID: 28652653
Aim: To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis. Methods: Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or...
4.
Shivaswamy V, Bennett R, Clure C, Ottemann B, Davis J, Larsen J, et al.
Transl Res
. 2013 Dec;
163(3):221-31.
PMID: 24361102
Although the contribution of the immunosuppressants tacrolimus (TAC) and sirolimus (SIR) to the development of posttransplant diabetes mellitus (PTDM) are being increasingly recognized, the mechanisms of immunosuppressant-induced hyperglycemia are unclear....
5.
Shivaswamy V, Bennett R, Clure C, Larsen J, Hamel F
Transplantation
. 2012 Dec;
95(2):280-4.
PMID: 23250335
Background: Immunosuppressants are an important cause of posttransplantation diabetes mellitus. We have shown that tacrolimus and sirolimus induce hyperglycemia and hyperinsulinemia in normal rats. We hypothesized that metformin, given concurrently...
6.
Bennett R, Wakeley S, Hamel F, High R, Korch C, Goldner W
Oncology
. 2012 Sep;
83(5):264-72.
PMID: 22992568
The association between vitamin D and thyroid cancer is unclear. It is unknown if CYP27A1 or CYP2R1 are present in normal thyroid or cancer cells and there is limited information...
7.
Shivaswamy V, Ochsner L, Maroni D, Wang C, Passer J, Clure C, et al.
Transplantation
. 2011 Apr;
91(12):1333-9.
PMID: 21508897
Background: Immunosuppression medications contribute to posttransplant diabetes mellitus in patients and can cause insulin resistance in male rats. Tacrolimus (TAC)-sirolimus (SIR) immunosuppression is also associated with appearance of ovarian cysts...
8.
Cordes C, Bennett R, Siford G, Hamel F
PLoS One
. 2011 Mar;
6(3):e18138.
PMID: 21448434
Insulin-degrading enzyme (IDE) is a thiol sensitive peptidase that degrades insulin and amyloid β, and has been linked to type 2 diabetes mellitus and Alzheimer's disease. We examined the thiol...
9.
Desouza C, Hamel F, Bidasee K, OConnell K
Diabetes
. 2011 Feb;
60(4):1286-94.
PMID: 21346178
Objective: Endothelial progenitor cells (EPCs) are decreased in number and function in type 2 diabetes. Mechanisms by which this dysfunction occurs are largely unknown. We tested the hypothesis that a...
10.
Shivaswamy V, McClure M, Passer J, Frahm C, Ochsner L, Erickson J, et al.
Endocrine
. 2010 Oct;
37(3):489-96.
PMID: 20960173
Post-transplant diabetes mellitus (PTDM) worsens outcomes after kidney transplantation, and immunosuppression agents contribute to PTDM. We have previously shown that tacrolimus (TAC) and sirolimus (SIR) cause hyperglycemia in normal rats....