Frederick A Mallette
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Explore the profile of Frederick A Mallette including associated specialties, affiliations and a list of published articles.
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52
Citations
2296
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Recent Articles
1.
Hajj-Boutros G, Faust A, Muscedere J, Kim P, Abumrad N, Chevalier S, et al.
J Gerontol A Biol Sci Med Sci
. 2024 Mar;
79(7).
PMID: 38486371
The inaugural Canadian Conferences on Translational Geroscience were held as 2 complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social...
2.
Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, et al.
Nat Med
. 2024 Feb;
30(2):443-454.
PMID: 38321220
Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME). Current standards of care for DME manage aspects of the disease,...
3.
Neault M, Lebert-Ghali C, Fournier M, Capdevielle C, Garfinkle E, Obermayer A, et al.
Cell Rep
. 2023 Sep;
42(9):113084.
PMID: 37716355
Pediatric acute megakaryoblastic leukemia (AMKL) is an aggressive blood cancer associated with poor therapeutic response and high mortality. Here we describe the development of CBFA2T3-GLIS2-driven mouse models of AMKL that...
4.
Pinedo-Carpio E, Dessapt J, Beneyton A, Sacre L, Berube M, Villot R, et al.
Sci Adv
. 2023 Aug;
9(32):eadf4082.
PMID: 37556550
Interstrand DNA cross-links (ICLs) represent complex lesions that compromise genomic stability. Several pathways have been involved in ICL repair, but the extent of factors involved in the resolution of ICL-induced...
5.
Mawambo G, Oubaha M, Ichiyama Y, Blot G, Crespo-Garcia S, Dejda A, et al.
J Neuroinflammation
. 2023 Jun;
20(1):145.
PMID: 37344842
Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of...
6.
Barbour H, Nkwe N, Estavoyer B, Messmer C, Gushul-Leclaire M, Villot R, et al.
iScience
. 2023 May;
26(5):106276.
PMID: 37168555
Ubiquitination is an important post-translational modification (PTM) that regulates a large spectrum of cellular processes in eukaryotes. Abnormalities in ubiquitin signaling underlie numerous human pathologies including cancer and neurodegeneration. Much...
7.
Prabhu S, Moussa O, Goncalves C, LaPierre J, Chou H, Huang F, et al.
Mol Cancer Ther
. 2023 Feb;
22(2):192-204.
PMID: 36722142
Aberrant cell-cycle progression is characteristic of melanoma, and CDK4/6 inhibitors, such as palbociclib, are currently being tested for efficacy in this disease. Despite the promising nature of CDK4/6 inhibitors, their...
8.
Fournier F, Diaz-Marin R, Pilon F, Neault M, Juneau R, Girouard G, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2209973120.
PMID: 36574648
Obesity is a major risk factor for cancer. Conventional thought suggests that elevated adiposity predisposes to heightened inflammatory stress and potentiates tumor growth, yet underlying mechanisms remain ill-defined. Here, we...
9.
Lemay J, St-Hilaire E, Ronato D, Gao Y, Belanger F, Gezzar-Dandashi S, et al.
PLoS Biol
. 2022 Oct;
20(10):e3001543.
PMID: 36215310
Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RFs). At blocked RF, single-stranded DNA (ssDNA)...
10.
Villot R, Poirier A, Devillers R, Kolnoguz A, Elowe S, Manem V, et al.
Mol Cell Oncol
. 2022 Apr;
8(6):1985930.
PMID: 35419475
We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle...