Fred E Regnier
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Explore the profile of Fred E Regnier including associated specialties, affiliations and a list of published articles.
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80
Citations
2206
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Recent Articles
1.
Narsimhan M, Kim J, Morris N, Bower M, Gunawardena H, Bowen E, et al.
Anal Chem
. 2023 Oct;
95(44):16115-16122.
PMID: 37883730
Federal regulatory agencies require continuous verification of recombinant therapeutic monoclonal antibody (mAb) quality that is commonly achieved in a two-step process. First, the host-cell proteome and metabolome are removed from...
2.
Li Z, Kim J, Regnier F
Anal Chem
. 2017 Dec;
90(3):1668-1676.
PMID: 29260867
The objective in routine analyses is generally to determine a small number of analytes. With samples containing ∼10 or more components there will be insufficient peak capacity to resolve analytes...
3.
4.
Abbatiello S, Schilling B, Mani D, Zimmerman L, Hall S, MacLean B, et al.
Mol Cell Proteomics
. 2015 Feb;
14(9):2357-74.
PMID: 25693799
There is an increasing need in biology and clinical medicine to robustly and reliably measure tens to hundreds of peptides and proteins in clinical and biological samples with high sensitivity,...
5.
Regnier F, Kim J
Bioanalysis
. 2014 Nov;
6(19):2685-98.
PMID: 25411709
Sample preparation has lagged far behind the evolution of instrumentation used in mass-linked protein analysis. Trypsin digestion, for example, still takes a day, as it did 50 years ago, while...
6.
Kim J, Woenker T, Adamec J, Regnier F
Anal Chem
. 2013 Oct;
85(23):11501-8.
PMID: 24156552
A rapid plasma extraction technology that collects a 2.5 μL aliquot of plasma within three minutes from a finger-stick derived drop of blood was evaluated. The utility of the plasma...
7.
Rivera-Burgos D, Regnier F
J Sep Sci
. 2013 Jan;
36(3):454-60.
PMID: 23281316
Trypsin digestion is a major component of preparing proteins for peptide based identification and quantification by mass spectral (MS) analysis. Surprisingly proteolysis is the slowest part of the proteomics process...
8.
Madian A, Rochelle N, Regnier F
Anal Chem
. 2012 Sep;
85(2):737-48.
PMID: 22950521
No abstract available.
9.
Rivera-Burgos D, Regnier F
Anal Chem
. 2012 Aug;
84(16):7021-8.
PMID: 22845770
Trypsin concentration and the unmasking of cleavage sites in proteins play important roles in the stoichiometry of peptide production and the number of limit peptides generated during proteolysis. The hypothesis...
10.
Madian A, Hindupur J, Hulleman J, Diaz-Maldonado N, Mishra V, Guigard E, et al.
Mol Cell Proteomics
. 2011 Nov;
11(2):M111.010892.
PMID: 22104028
Mutations in the gene encoding DJ-1 have been identified in patients with familial Parkinson's disease (PD) and are thought to inactivate a neuroprotective function. Oxidation of the sulfhydryl group to...