Frauke Ackermann
Overview
Explore the profile of Frauke Ackermann including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
348
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Recent Articles
1.
Michanski S, Kapoor R, Steyer A, Mobius W, Fruholz I, Ackermann F, et al.
EMBO Rep
. 2023 Jul;
24(9):e56702.
PMID: 37477166
Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly transmit sound information at high rates over long time periods with extreme temporal precision. This...
2.
van Casteren A, Ackermann F, Rahman K, Andrzejak E, Rosenmund C, Kreye J, et al.
eNeuro
. 2022 Nov;
9(6).
PMID: 36446572
Autoantibodies against central nervous system proteins are increasingly being recognized in association with neurologic disorders. Although a growing number of neural autoantibodies have been identified, a causal link between specific...
3.
Garner C, Ackermann F
Mol Cell Neurosci
. 2022 Nov;
124:103795.
PMID: 36436725
Properly working synapses are one important guarantor for a functional and healthy brain. They are small, densely packed structures, where information is transmitted through the release of neurotransmitters from synaptic...
4.
Andrzejak E, Rabinovitch E, Kreye J, Pruss H, Rosenmund C, Ziv N, et al.
J Neurosci
. 2022 Mar;
42(15):3253-3270.
PMID: 35241491
Anti-NMDA receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder associated with autoantibodies against NMDARs, which cause a variety of symptoms from prominent psychiatric and cognitive manifestations to seizures and autonomic...
5.
Falck J, Bruns C, Hoffmann-Conaway S, Straub I, Plautz E, Orlando M, et al.
J Neurosci
. 2020 Mar;
40(14):2943-2959.
PMID: 32122952
Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric...
6.
Ackermann F, Schink K, Bruns C, Izsvak Z, Hamra F, Rosenmund C, et al.
Elife
. 2019 May;
8.
PMID: 31074746
Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation...
7.
Wenke N, Kreye J, Andrzejak E, van Casteren A, Leubner J, Murgueitio M, et al.
Ann Neurol
. 2019 Mar;
85(5):771-776.
PMID: 30843274
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to autoantibody-mediated synaptic dysfunction. Cerebrospinal fluid-derived human monoclonal NR1 autoantibodies showed low numbers of somatic hypermutations or were unmutated....
8.
Muller T, Gierke K, Joachimsthaler A, Sticht H, Izsvak Z, Hamra F, et al.
J Neurosci
. 2019 Jan;
39(14):2606-2619.
PMID: 30696732
Active zones at chemical synapses are highly specialized sites for the regulated release of neurotransmitters. Despite a high degree of active zone protein conservation in vertebrates, every type of chemical...
9.
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, et al.
J Neurosci
. 2019 Jan;
39(12):2163-2183.
PMID: 30655355
The regulated turnover of synaptic vesicle (SV) proteins is thought to involve the ubiquitin-dependent tagging and degradation through endo-lysosomal and autophagy pathways. Yet, it remains unclear which of these pathways...
10.
Nigam S, Xu S, Ackermann F, Gregory J, Lundkvist J, Lendahl U, et al.
Neurosci Res
. 2016 Feb;
109:9-15.
PMID: 26907521
BACE1-mediated cleavage of APP is a pivotal step in the production of the Alzheimer related Aβ peptide and inhibitors of BACE1 are currently in clinical development for the treatment of...