Frantisek Supek
Overview
Explore the profile of Frantisek Supek including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
981
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0
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Recent Articles
1.
Koester D, Marx V, Williams S, Jiricek J, Dauphinais M, Rene O, et al.
J Med Chem
. 2022 Aug;
65(17):11776-11787.
PMID: 35993839
Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the genus. The disease proceeds in two stages, with a hemolymphatic blood stage and a meningo-encephalic brain...
2.
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, et al.
J Med Chem
. 2020 Jul;
63(19):10773-10781.
PMID: 32667203
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of...
3.
Saldivia M, Fang E, Ma X, Myburgh E, Carnielli J, Bower-Lepts C, et al.
Nat Microbiol
. 2020 Jul;
5(10):1207-1216.
PMID: 32661312
The kinetochore is a macromolecular structure that assembles on the centromeres of chromosomes and provides the major attachment point for spindle microtubules during mitosis. In Trypanosoma brucei, the proteins that...
4.
Rao S, Lakshminarayana S, Jiricek J, Kaiser M, Ritchie R, Myburgh E, et al.
Trop Med Infect Dis
. 2020 Feb;
5(1).
PMID: 32079320
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and 'easy to use' oral drugs. Previously,...
5.
Ozcelik D, Seto A, Rakic B, Farzam A, Supek F, Pezacki J
ACS Omega
. 2019 Feb;
3(12):17227-17235.
PMID: 30775641
Protein disulfide isomerases (PDIs) catalyze disulfide bond formation between protein cysteine residues during protein folding in the endoplasmic reticulum (ER) lumen and are essential for maintaining ER homoeostasis. The life...
6.
Mehta A, Supekova L, Chen J, Pestonjamasp K, Webster P, Ko Y, et al.
Proc Natl Acad Sci U S A
. 2018 Oct;
115(46):11796-11801.
PMID: 30373839
It has been hypothesized that mitochondria evolved from a bacterial ancestor that initially became established in an archaeal host cell as an endosymbiont. Here we model this first stage of...
7.
Khare S, Nagle A, Biggart A, Lai Y, Liang F, Davis L, et al.
Nature
. 2016 Aug;
537(7619):229-233.
PMID: 27501246
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually. The diseases are caused by infection with the kinetoplastid parasites Trypanosoma...
8.
Khare S, Liu X, Stinson M, Rivera I, Groessl T, Tuntland T, et al.
Antimicrob Agents Chemother
. 2015 Aug;
59(10):6385-94.
PMID: 26239982
Two CYP51 inhibitors, posaconazole and the ravuconazole prodrug E1224, were recently tested in clinical trials for efficacy in indeterminate Chagas disease. The results from these studies show that both drugs...
9.
Khare S, Roach S, Barnes S, Hoepfner D, Walker J, Chatterjee A, et al.
PLoS Pathog
. 2015 Jul;
11(7):e1005058.
PMID: 26186534
Unbiased phenotypic screens enable identification of small molecules that inhibit pathogen growth by unanticipated mechanisms. These small molecules can be used as starting points for drug discovery programs that target...
10.
Nagle A, Khare S, Kumar A, Supek F, Buchynskyy A, Mathison C, et al.
Chem Rev
. 2014 Nov;
114(22):11305-47.
PMID: 25365529
No abstract available.