Frank Wessely
Overview
Explore the profile of Frank Wessely including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
295
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0
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Recent Articles
1.
Kurtyka M, Wessely F, Bau S, Ifie E, He L, de Wit N, et al.
Eur J Cell Biol
. 2024 Mar;
103(2):151406.
PMID: 38547677
Despite extensive research, targeted delivery of substances to the brain still poses a great challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require either carrier- or...
2.
Tsartsalis S, Sleven H, Fancy N, Wessely F, Smith A, Willumsen N, et al.
Nat Commun
. 2024 Mar;
15(1):2243.
PMID: 38472200
Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer's disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains...
3.
Booth H, Wessely F, Connor-Robson N, Rinaldi F, Vowles J, Browne C, et al.
Neurobiol Dis
. 2019 May;
129:56-66.
PMID: 31085228
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is one of the most common known causes...
4.
Volpato V, Smith J, Sandor C, Ried J, Baud A, Handel A, et al.
Stem Cell Reports
. 2018 Sep;
11(4):897-911.
PMID: 30245212
Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of...
5.
Baud A, Wessely F, Mazzacuva F, McCormick J, Camuzeaux S, Heywood W, et al.
Anal Chem
. 2017 Feb;
89(4):2440-2448.
PMID: 28192931
Induced pluripotent stem cells have great potential as a human model system in regenerative medicine, disease modeling, and drug screening. However, their use in medical research is hampered by laborious...
6.
Shore A, Emes R, Wessely F, Kemp P, Cillo C, DArmiento M, et al.
Front Genet
. 2013 Jan;
3:304.
PMID: 23293654
The thermoregulatory function of brown adipose tissue (BAT) is due to the tissue-specific expression of uncoupling protein 1 (UCP1) which is thought to have evolved in early mammals. We report...
7.
Fainberg H, Bodley K, Bacardit J, Li D, Wessely F, Mongan N, et al.
PLoS One
. 2012 Nov;
7(11):e49101.
PMID: 23155453
The Meishan pig breed exhibits increased prolificacy and reduced neonatal mortality compared to commercial breeds, such as the Large White, prompting breeders to introduce the Meishan genotype into commercial herds....
8.
Duong C, Emes R, Wessely F, Yacqub-Usman K, Clayton R, Farrell W
Endocr Relat Cancer
. 2012 Oct;
19(6):805-16.
PMID: 23045325
DNA methylation is one of the several epigenetic modifications that together with genetic aberrations are hallmarks of tumorigenesis including those emanating from the pituitary gland. In this study, we examined...
9.
Wessely F, Emes R
Front Genet
. 2012 Sep;
3:161.
PMID: 22936948
Epigenetic modifications of DNA, such as cytosine methylation are differentially abundant in diseases such as cancer. A goal for clinical research is finding sites that are differentially methylated between groups...
10.
Clifford H, Wessely F, Pendurthi S, Emes R
Front Genet
. 2012 Feb;
2:88.
PMID: 22303382
The use of genome-wide methylation arrays has proved very informative to investigate both clinical and biological questions in human epigenomics. The use of clustering methods either for exploration of these...