Frank Weekers
Overview
Explore the profile of Frank Weekers including associated specialties, affiliations and a list of published articles.
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10
Citations
360
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Recent Articles
1.
Marquet K, Claes N, De Troy E, Kox G, Droogmans M, Schrooten W, et al.
Crit Care Med
. 2015 Mar;
43(5):1053-61.
PMID: 25756416
Objective: The objectives of this study are to determine the prevalence and preventability of adverse events requiring an unplanned higher level of care, defined as an unplanned transfer to the...
2.
Vlayen A, Marquet K, Schrooten W, Vleugels A, Hellings J, De Troy E, et al.
BMC Res Notes
. 2012 Aug;
5:468.
PMID: 22931859
Background: Adverse events are unintended patient injuries that arise from healthcare management resulting in disability, prolonged hospital stay or death. Adverse events that require intensive care admission imply a considerable...
3.
Thijssen-Timmer D, Peeters R, Wouters P, Weekers F, Visser T, Fliers E, et al.
Thyroid
. 2007 Feb;
17(2):105-12.
PMID: 17316111
Objective: The THRA gene encodes two isoforms of the thyroid hormone receptor (TR), TRalpha1 and TRalpha2. The ratio of these splice variants could have a marked influence on T3-regulated gene...
4.
Weekers F, Van den Berghe G
Proc Nutr Soc
. 2004 Sep;
63(3):443-50.
PMID: 15373956
The ongoing hypermetabolic response in patients with prolonged critical illness leads to the loss of lean tissue mass. Since the cachexia of prolonged illness is usually associated with low concentrations...
5.
Weekers F, Michalaki M, Coopmans W, Van Herck E, Veldhuis J, Darras V, et al.
Endocrinology
. 2003 Oct;
145(1):205-13.
PMID: 14551231
Treatment with recombinant human GH (rhGH) increases the mortality of critical illness. We postulated that combined GH-releasing peptide-2 (GHRP-2), TRH, and insulin infusion is a less toxic anabolic strategy through...
6.
Weekers F, Giulietti A, Michalaki M, Coopmans W, Van Herck E, Mathieu C, et al.
Endocrinology
. 2003 Sep;
144(12):5329-38.
PMID: 12960028
Stress hyperglycemia is frequent in critically ill patients. The aim of this study was to investigate the effect of blood glucose control with insulin on endocrine, metabolic, and immune function...
7.
Van den Berghe G, Wouters P, Bouillon R, Weekers F, Verwaest C, Schetz M, et al.
Crit Care Med
. 2003 Feb;
31(2):359-66.
PMID: 12576937
Objectives: Maintenance of normoglycemia with insulin reduces mortality and morbidity of critically ill patients. Here we report the factors determining insulin requirements and the impact of insulin dose vs. blood...
8.
Mesotten D, Delhanty P, Vanderhoydonc F, Hardman K, Weekers F, Baxter R, et al.
J Clin Endocrinol Metab
. 2002 Dec;
87(12):5516-23.
PMID: 12466347
IGF binding protein-1 (IGFBP-1), an important regulator of IGF bioavailability, has been shown to correlate with mortality in critically ill patients. In the liver, IGFBP-1 is transcriptionally repressed by insulin,...
9.
Van den Berghe G, Baxter R, Weekers F, Wouters P, Bowers C, Iranmanesh A, et al.
Clin Endocrinol (Oxf)
. 2002 May;
56(5):655-69.
PMID: 12030918
Objective: Central hyposomatotrophism, hypothyroidism and hypogonadism are present concomitantly in men with prolonged critical illness. This study evaluated the impact of combined treatment with GH-releasing peptide-2 (GHRP-2), TRH and GnRH...
10.
Weekers F, Van Herck E, Coopmans W, Michalaki M, Bowers C, Veldhuis J, et al.
Endocrinology
. 2002 Feb;
143(3):764-74.
PMID: 11861495
High doses of GH, used to induce anabolism in prolonged critically ill patients, unexpectedly increased mortality. To further explore underlying mechanisms, a valid animal model is needed. Such a model...