Frank F Heisler
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Explore the profile of Frank F Heisler including associated specialties, affiliations and a list of published articles.
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12
Citations
331
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Recent Articles
1.
Radwitz J, Hausrat T, Heisler F, Janiesch P, Pechmann Y, Rubhausen M, et al.
Cell Mol Life Sci
. 2022 Oct;
79(11):575.
PMID: 36309617
Microtubules are dynamic polymers of α/β-tubulin. They regulate cell structure, cell division, cell migration, and intracellular transport. However, functional contributions of individual tubulin isotypes are incompletely understood. The neuron-specific β-tubulin...
2.
Muhia M, Yuanxiang P, Sedlacik J, Schwarz J, Heisler F, Gromova K, et al.
Commun Biol
. 2022 Jun;
5(1):589.
PMID: 35705737
Muskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane receptor trafficking. However, its influence on intrinsic brain activity and corresponding behavioral processes remains unclear. Here we show that murine...
3.
Brachet A, Lario A, Fernandez-Rodrigo A, Heisler F, Gutierrez Y, Lobo C, et al.
Cell Rep
. 2021 Aug;
36(5):109499.
PMID: 34348158
The synaptic removal of AMPA-type glutamate receptors (AMPARs) is a core mechanism for hippocampal long-term depression (LTD). In this study, we address the role of microtubule-dependent transport of AMPARs as...
4.
Kneussel M, Sanchez-Rodriguez N, Mischak M, Heisler F
iScience
. 2021 May;
24(5):102416.
PMID: 33997696
Protein transport toward the nucleus is important for translating molecular signals into gene expression changes. Interestingly, the unconventional motor protein myosin VI regulates RNA polymerase II-dependent gene transcription. Whether actin-filament-dependent...
5.
Lopes A, Hausrat T, Heisler F, Gromova K, Lombino F, Fischer T, et al.
PLoS Biol
. 2020 Sep;
18(8):e3000820.
PMID: 32866173
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [cHSP])...
6.
Wagner W, Lippmann K, Heisler F, Gromova K, Lombino F, Roesler M, et al.
Cell Rep
. 2019 Jul;
28(1):11-20.e9.
PMID: 31269433
Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons. We...
7.
Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, et al.
Neuron
. 2018 Sep;
99(6):1155-1169.e9.
PMID: 30174115
Cellular prion protein (PrP) modulates cell adhesion and signaling in the brain. Conversion to its infectious isoform causes neurodegeneration, including Creutzfeldt-Jakob disease in humans. PrP undergoes rapid plasma membrane turnover...
8.
Hausrat T, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, et al.
Nat Commun
. 2015 Apr;
6:6872.
PMID: 25891999
Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addition, lateral diffusion and confinement exchanges...
9.
Delto C, Heisler F, Kuper J, Sander B, Kneussel M, Schindelin H
Structure
. 2015 Jan;
23(2):364-73.
PMID: 25579817
Neurons regulate the number of surface receptors by balancing the transport to and from the plasma membrane to adjust their signaling properties. The protein muskelin was recently identified as a...
10.
Heisler F, Lee H, Gromova K, Pechmann Y, Schurek B, Ruschkies L, et al.
Proc Natl Acad Sci U S A
. 2014 Mar;
111(13):5030-5.
PMID: 24639525
The GluA2 subunit of AMPA-type glutamate receptors (AMPARs) regulates excitatory synaptic transmission in neurons. In addition, the transsynaptic cell adhesion molecule N-cadherin controls excitatory synapse function and stabilizes dendritic spine...