Frank C P Holstege
Overview
Explore the profile of Frank C P Holstege including associated specialties, affiliations and a list of published articles.
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121
Citations
5019
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Recent Articles
11.
van Belzen I, van Tuil M, Badloe S, Strengman E, Janse A, Verwiel E, et al.
Cancers (Basel)
. 2022 Oct;
14(19).
PMID: 36230794
Chromosomal alterations have recurrently been identified in Wilms tumors (WTs) and some are associated with poor prognosis. Gain of 1q (1q+) is of special interest given its high prevalence and...
12.
Langenberg K, Meister M, Bakhuizen J, Boer J, van Eijkelenburg N, Hulleman E, et al.
Eur J Cancer
. 2022 Oct;
175:311-325.
PMID: 36182817
iTHER is a Dutch prospective national precision oncology program aiming to define tumour molecular profiles in children and adolescents with primary very high-risk, relapsed, or refractory paediatric tumours. Between April...
13.
Lu P, Kirlin A, Aristizabal M, Brewis H, Levesque N, Setiaputra D, et al.
Genetics
. 2022 Sep;
222(3).
PMID: 36066422
The NuA4 lysine acetyltransferase complex acetylates histone and nonhistone proteins and functions in transcription regulation, cell cycle progression, and DNA repair. NuA4 harbors an interesting duality in that its catalytic...
14.
Meister M, Groot Koerkamp M, de Souza T, Breunis W, Frazer-Mendelewska E, Brok M, et al.
EMBO Mol Med
. 2022 Aug;
14(10):e16001.
PMID: 35916583
Rhabdomyosarcomas (RMS) are mesenchyme-derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high-risk patients. Discovery of new therapies would benefit...
15.
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
Morris V, Wang D, Li Z, Marion W, Hughes T, Sousa P, et al.
Cell Rep
. 2022 Apr;
39(4):110752.
PMID: 35476984
High-risk forms of B-acute lymphoblastic leukemia (B-ALL) remain a therapeutic challenge. Leukemia-initiating cells (LICs) self-renew and spark relapse and therefore have been the subject of intensive investigation; however, the properties...
16.
Hehir-Kwa J, Koudijs M, Verwiel E, Kester L, van Tuil M, Strengman E, et al.
JCO Precis Oncol
. 2022 Jan;
6:e2000504.
PMID: 35085008
Purpose: Gene fusions play a significant role in cancer etiology, making their detection crucial for accurate diagnosis, prognosis, and determining therapeutic targets. Current diagnostic methods largely focus on either targeted...
17.
Daub J, Amini S, Kersjes D, Ma X, Jager N, Zhang J, et al.
Commun Biol
. 2021 Oct;
4(1):1139.
PMID: 34615983
Childhood cancer is a major cause of child death in developed countries. Genetic interactions between mutated genes play an important role in cancer development. They can be detected by searching...
18.
Bao X, Koorengevel M, Groot Koerkamp M, Homavar A, Weijn A, Crielaard S, et al.
EMBO J
. 2021 Sep;
40(20):e107966.
PMID: 34520050
Phosphatidylcholine (PC) is an abundant membrane lipid component in most eukaryotes, including yeast, and has been assigned multiple functions in addition to acting as building block of the lipid bilayer....
19.
Candelli T, Schneider P, Castro P, Jones L, Bodewes E, Rockx-Brouwer D, et al.
Leukemia
. 2021 Jul;
36(1):58-67.
PMID: 34304246
Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intense therapy to counter a highly aggressive malignancy with survival rates of only 30-40%. The majority of patients initially show...
20.
Zelco A, Borjesson V, de Kanter J, Lebrero-Fernandez C, Lauschke V, Rocha-Ferreira E, et al.
Genes Dev
. 2021 Jul;
35(15-16):1190-1207.
PMID: 34301765
The meninges are important for brain development and pathology. Using single-cell RNA sequencing, we have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes under normal conditions and...