Frank C Nichols
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Explore the profile of Frank C Nichols including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
11.
Nichols F, Bhuse K, Clark R, Provatas A, Carrington E, Wang Y, et al.
Front Oral Health
. 2022 Jan;
2:698481.
PMID: 35048038
Toll-like receptor 2 (TLR2) activation has been implicated in the pathogenesis of periodontal disease but the identity of the TLR2 agonists has been an evolving story. The serine/glycine lipids produced...
12.
Nichols F, Clark R, Maciejewski M, Provatas A, Balsbaugh J, Dewhirst F, et al.
J Lipid Res
. 2020 Sep;
61(12):1645-1657.
PMID: 32912852
is a Gram-negative anaerobic periodontal microorganism strongly associated with tissue-destructive processes in human periodontitis. Following oral infection with the periodontal bone loss in mice is reported to require the engagement...
13.
Nichols F, Clark R, Liu Y, Provatas A, Dietz C, Zhu Q, et al.
Infect Immun
. 2020 Jan;
88(4).
PMID: 31932327
The serine-glycine dipeptide lipid classes, including lipid 430 and lipid 654, are produced by the periodontal pathogen and can be detected in lipid extracts of diseased periodontal tissues and teeth...
14.
Wasko N, Kulak M, Paul D, Nicaise A, Yeung S, Nichols F, et al.
J Neuroinflammation
. 2019 Jul;
16(1):158.
PMID: 31351476
Background: Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination. Studies indicate that Toll-like receptor 2 (TLR2) signaling contributes to...
15.
Olsen I, Nichols F
Infect Immun
. 2018 Apr;
86(7).
PMID: 29632248
The keystone periodontal pathogen produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) lipids. Phosphorylated DHCs (PDHCs) from can affect a number of...
16.
Nemati R, Dietz C, Anstadt E, Cervantes J, Liu Y, Dewhirst F, et al.
J Lipid Res
. 2017 Aug;
58(10):1999-2007.
PMID: 28814639
Multiple reaction monitoring-MS analysis of lipid extracts from human carotid endarterectomy and carotid artery samples from young individuals consistently demonstrated the presence of bacterial serine dipeptide lipid classes, including Lipid...
17.
Dietz C, Clark R, Nichols F, Smith M
J Labelled Comp Radiopharm
. 2017 Mar;
60(6):274-285.
PMID: 28271544
Bacterial serine dipeptide lipids are known to promote inflammatory processes and are detected in human tissues associated with periodontal disease or atherosclerosis. Accurate quantification of bacterial serine lipid, specifically lipid...
18.
Kanzaki H, Movila A, Kayal R, Napimoga M, Egashira K, Dewhirst F, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2017 Feb;
1862(5):452-462.
PMID: 28153611
Among several virulence factors produced by the periodontal pathogen Porphyromonas gingivalis (Pg), a recently identified novel class of dihydroceramide lipids that contains a long acyl-chain has the potential to play...
19.
Moye Z, Valiuskyte K, Dewhirst F, Nichols F, Davey M
Front Microbiol
. 2016 Dec;
7:1919.
PMID: 27965646
Bacteria alter the biophysical properties of their membrane lipids in response to environmental cues, such as shifts in pH or temperature. In essence, lipid composition determines membrane structure, which in...
20.
Doona C, Feeherry F, Setlow B, Wang S, Li W, Nichols F, et al.
Appl Environ Microbiol
. 2016 Jun;
82(17):5287-97.
PMID: 27316969
Unlabelled: This work analyzes the high-pressure (HP) germination of spores of the food-borne pathogen Clostridium perfringens (with inner membrane [IM] germinant receptors [GRs]) and the opportunistic pathogen Clostridium difficile (with...