Francois Gaudet
Overview
Explore the profile of Francois Gaudet including associated specialties, affiliations and a list of published articles.
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11
Citations
1868
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Recent Articles
1.
Pillarisetti K, Powers G, Luistro L, Babich A, Baldwin E, Li Y, et al.
Blood Adv
. 2020 Sep;
4(18):4538-4549.
PMID: 32956453
B-cell maturation antigen (BCMA), a member of the tumor necrosis factor family of receptors, is predominantly expressed on the surface of terminally differentiated B cells. BCMA is highly expressed on...
2.
Nair-Gupta P, Rudnick S, Luistro L, Smith M, McDaid R, Li Y, et al.
Blood Cancer J
. 2020 Jun;
10(6):65.
PMID: 32483120
Redirecting T cells to specifically kill malignant cells has been validated as an effective anti-cancer strategy in the clinic with the approval of blinatumomab for acute lymphoblastic leukemia. However, the...
3.
Nair-Gupta P, Diem M, Reeves D, Wang W, Schulingkamp R, Sproesser K, et al.
Blood Adv
. 2020 Mar;
4(5):906-919.
PMID: 32150609
CD33 is expressed in 90% of patients with acute myeloid leukemia (AML), and its extracellular portion consists of a V domain and a C2 domain. A recent study showed that...
4.
Pillarisetti K, Edavettal S, Mendonca M, Li Y, Tornetta M, Babich A, et al.
Blood
. 2020 Feb;
135(15):1232-1243.
PMID: 32040549
T-cell-mediated approaches have shown promise in myeloma treatment. However, there are currently a limited number of specific myeloma antigens that can be targeted, and multiple myeloma (MM) remains an incurable...
5.
Frerichs K, Broekmans M, Marin Soto J, van Kessel B, Heymans M, Holthof L, et al.
Clin Cancer Res
. 2020 Jan;
26(9):2203-2215.
PMID: 31969333
Purpose: Multiple myeloma (MM) patients with disease refractory to all available drugs have a poor outcome, indicating the need for new agents with novel mechanisms of action. Experimental Design: We...
6.
Kaur M, Drake A, Hu G, Rudnick S, Chen Q, Phennicie R, et al.
J Immunol
. 2019 Feb;
202(6):1885-1894.
PMID: 30710044
Development of targeted cancer therapy requires a thorough understanding of mechanisms of tumorigenesis as well as mechanisms of action of therapeutics. This is challenging because by the time patients are...
7.
Wang J, Hevi S, Kurash J, Lei H, Gay F, Bajko J, et al.
Nat Genet
. 2008 Dec;
41(1):125-9.
PMID: 19098913
Histone methylation and DNA methylation cooperatively regulate chromatin structure and gene activity. How these two systems coordinate with each other remains unclear. Here we study the biological function of lysine-specific...
8.
Kurash J, Lei H, Shen Q, Marston W, Granda B, Fan H, et al.
Mol Cell
. 2008 Feb;
29(3):392-400.
PMID: 18280244
The protein methyltransferase Set7/9 was recently shown to regulate p53 activity in cancer cells. However, the impact of Set7/9 on p53 function in vivo is unclear. To explore these issues,...
9.
Gaudet F, Hodgson J, Eden A, Jackson-Grusby L, Dausman J, Gray J, et al.
Science
. 2003 Apr;
300(5618):489-92.
PMID: 12702876
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice...
10.
Eden A, Gaudet F, Waghmare A, Jaenisch R
Science
. 2003 Apr;
300(5618):455.
PMID: 12702868
No abstract available.