Francois Daubeuf
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    Explore the profile of Francois Daubeuf including associated specialties, affiliations and a list of published articles.
          
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              Articles
              40
            
            
              Citations
              377
            
            
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  Recent Articles
          1.
        
    
    Boos A, Most J, Cahuzac H, Moreira da Silva L, Daubeuf F, Erb S, et al.
  
  
    J Med Chem
    . 2024 Dec;
          68(1):695-705.
    
    PMID: 39680648
  
  
          Antibody-drug conjugates (ADCs) are a well-established class of therapeutics primarily used in oncology to selectively deliver highly cytotoxic agents into cancer cells. While ADCs should theoretically spare healthy tissues and...
      
2.
        
    
    Girault-Sotias P, Deloux R, De Mota N, Riche S, Daubeuf F, Iturrioz X, et al.
  
  
    Can J Cardiol
    . 2024 Dec;
    
    PMID: 39674544
  
  
          Background: To protect patients after myocardial infarction (MI) and preserve cardiac function, the development of new therapeutics remains an important issue. Apelin, a neuro-vasoactive peptide, increases aqueous diuresis and cardiac...
      
3.
        
    
    Jouvenel A, Tassou A, Thouaye M, Ruel J, Antri M, Leyris J, et al.
  
  
    Nat Commun
    . 2024 Nov;
          15(1):9633.
    
    PMID: 39511220
  
  
          Navigating the duality of opioids' potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic...
      
4.
        
    
    Neve J, Elhabazi K, Gonzalez S, Herby C, Schneider S, Utard V, et al.
  
  
    J Med Chem
    . 2024 Apr;
          67(9):7603-7619.
    
    PMID: 38687204
  
  
          The design of bifunctional compounds is a promising approach toward the development of strong analgesics with reduced side effects. We here report the optimization of the previously published lead peptide...
      
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    Lehot V, Neuberg P, Ripoll M, Daubeuf F, Erb S, Dovgan I, et al.
  
  
    Pharmaceutics
    . 2023 Jun;
          15(6).
    
    PMID: 37376091
  
  
          Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative...
      
6.
        
    
    Rady T, Turelli L, Nothisen M, Tobaldi E, Erb S, Thoreau F, et al.
  
  
    Bioconjug Chem
    . 2022 Sep;
          33(10):1860-1866.
    
    PMID: 36106863
  
  
          Cleavable linkers have become the subject of intense study in the field of chemical biology, particularly because of their applications in the construction of antibody-drug conjugates (ADC), where they facilitate...
      
7.
        
    
    Segaud J, Yao W, Marschall P, Daubeuf F, Lehalle C, German B, et al.
  
  
    Nat Commun
    . 2022 Sep;
          13(1):4703.
    
    PMID: 36050303
  
  
          Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic...
      
8.
        
    
    Schall N, Daubeuf F, Marsol C, Gizzi P, Frossard N, Bonnet D, et al.
  
  
    Front Pharmacol
    . 2021 Nov;
          12:752194.
    
    PMID: 34744730
  
  
          Dysregulation of CXCL12/SDF-1-CXCR4/CD184 signaling is associated with inflammatory diseases and notably with systemic lupus erythematosus. Issued from the lead molecule chalcone-4, the first neutraligand of the CXCL12 chemokine, LIT-927 was...
      
9.
        
    
    Daubeuf F, Schall N, Petit-Demouliere N, Frossard N, Muller S
  
  
    Cells
    . 2021 Sep;
          10(9).
    
    PMID: 34572117
  
  
          The involvement of autophagy and its dysfunction in asthma is still poorly documented. By using a murine model of chronic house dust mite (HDM)-induced airway inflammation, we tested the expression...
      
10.
        
    
    Nemska S, Daubeuf F, Obrecht A, Israel-Biet D, Stern M, Kessler R, et al.
  
  
    Transplantation
    . 2021 Feb;
          105(6):1212-1224.
    
    PMID: 33560725
  
  
          Background: Chronic lung allograft dysfunction (CLAD) and its obstructive form, the obliterative bronchiolitis (OB), are the main long-term complications related to high mortality rate postlung transplantation. CLAD treatment lacks a...