Context-dependent Function of TSLP and IL-1β in Skin Allergic Sensitization and Atopic March

Overview

Journal Nat Commun

Specialty Biology

Date 2022 Sep 1

PMID 36050303

Authors

Justine Segaud

Wenjin Yao

Pierre Marschall

Francois Daubeuf

Christine Lehalle

Beatriz German

Pierre Meyer

Pierre Hener

Cecile Hugel

Eric Flatter

Marine Guivarch

Laetitia Clauss

Stefan F Martin

Mustapha Oulad-Abdelghani

Mei Li

Affiliations

Soon will be listed here.

Abstract

Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma.

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