Franck Slowinski
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Explore the profile of Franck Slowinski including associated specialties, affiliations and a list of published articles.
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8
Citations
99
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Recent Articles
1.
Griebel G, Stemmelin J, Lopez-Grancha M, Boulay D, Boquet G, Slowinski F, et al.
Sci Rep
. 2019 Dec;
9(1):18045.
PMID: 31792284
Glycogen synthase kinase 3 (GSK3) has been identified as a promising target for the treatment of Alzheimer's disease (AD), where abnormal activation of this enzyme has been associated with hyperphosphorylation...
2.
Griebel G, Stemmelin J, Lopez-Grancha M, Fauchey V, Slowinski F, Pichat P, et al.
Sci Rep
. 2018 Feb;
8(1):2416.
PMID: 29403000
Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) represents the primary degradation enzyme of the...
3.
Griebel G, Pichat P, Boulay D, Naimoli V, Potestio L, Featherstone R, et al.
Sci Rep
. 2016 Oct;
6:35320.
PMID: 27734956
Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies describe a potent brain penetrant mGluR2 positive allosteric modulator...
4.
Le Falher L, Ben Ayad O, Ziyaret O, Mamontov A, Botuha C, Thorimbert S, et al.
J Org Chem
. 2014 Jun;
79(14):6579-89.
PMID: 24960188
Pyridyl-substituted 1,3,5-triazines were synthesized in good to excellent yields via an unprecedented one-step cyclocondensation of 4H-pyrido[1,3]oxazin-4-ones with amidines at room temperature or under microwave irradiations. The broad applicability was demonstrated...
5.
Slowinski F, Ben Ayad O, Ziyaret O, Botuha C, Le Falher L, Aouane K, et al.
Org Lett
. 2013 Jul;
15(14):3494-7.
PMID: 23829313
Unreported 2-substituted 4H-pyrido[e][1,3]oxazin-4-ones are synthesized via an unprecedented intramolecular O-arylation of N-aroyl- and N-heteroaroyl-(iso)nicotinamides under microwave irradiations, in good to excellent yields. The broad applicability was demonstrated by 24 examples...
6.
Slowinski F, Ben Ayad O, Vache J, Saady M, Leclerc O, Lochead A
J Org Chem
. 2011 Sep;
76(20):8336-46.
PMID: 21923123
Azabicyclo[2.2.1]heptane and -[3.3.1]nonane scaffolds (X = Cl, Br) containing a pyridinyl substituent at the bridgehead position were prepared via two complementary chemical pathways, either by the transformation of a methoxy...
7.
Slowinski F, Ben Ayad O, Vache J, Saady M, Leclerc O, Lochead A
Org Lett
. 2010 Oct;
12(21):5004-7.
PMID: 20939603
New azabicyclo[2.2.1]heptane and -[3.3.1]nonane derivatives containing a pyridinyl substituent at the bridgehead position have been synthesized via an efficient ten chemical steps pathway. Both chemical series were then evaluated in...
8.
Slowinski F, Aubert C, Malacria M
J Org Chem
. 2003 Jan;
68(2):378-86.
PMID: 12530863
Variously substituted linear enediynes phosphines oxides possessing the double bond at either the terminal or internal position and with the phosphine oxide appended onto the alkyne or the alkene terminus...