Francisca Alcaraz-Perez
Overview
Explore the profile of Francisca Alcaraz-Perez including associated specialties, affiliations and a list of published articles.
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18
Citations
439
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Recent Articles
1.
Hernandez-Silva D, Lopez-Abellan M, Martinez-Navarro F, Garcia-Castillo J, Cayuela M, Alcaraz-Perez F
Aging Cell
. 2025 Feb;
:e70007.
PMID: 39921881
Increased life expectancy is associated with a higher risk of age-related diseases, which represent a major public health challenge. Animal models play a crucial role in aging research, enabling the...
2.
Gaitan-Penas H, Perez-Rius C, Muhaisen A, Castellanos A, Errasti-Murugarren E, Barrallo-Gimeno A, et al.
J Physiol
. 2024 Jul;
602(16):3975-3994.
PMID: 39031529
The function of the chloride channel ClC-1 is crucial for the control of muscle excitability. Thus, reduction of ClC-1 functions by CLCN1 mutations leads to myotonia congenita. Many different animal...
3.
Martinez-Balsalobre E, Garcia-Castillo J, Garcia-Moreno D, Naranjo-Sanchez E, Fernandez-Lajarin M, Blasco M, et al.
Nat Commun
. 2023 Sep;
14(1):5912.
PMID: 37737237
Telomerase RNA (TERC) has a noncanonical function in myelopoiesis binding to a consensus DNA binding sequence and attracting RNA polymerase II (RNA Pol II), thus facilitating myeloid gene expression. The...
4.
Martinez-Lopez A, Tyrkalska S, Alcaraz-Perez F, Cabas I, Candel S, Martinez Morcillo F, et al.
Dev Comp Immunol
. 2023 Apr;
145:104710.
PMID: 37080369
Fish are the most diverse and successful group of vertebrate animals, with about 30,000 species. The study of fish immunity is of great importance for understanding the evolution of vertebrate...
5.
Hernandez-Silva D, Alcaraz-Perez F, Perez-Sanchez H, Cayuela M
Expert Opin Drug Discov
. 2022 Nov;
18(8):903-915.
PMID: 36383405
Introduction: The combination of Virtual Screening (VS) techniques with in screening in the zebrafish model is currently being used in tandem for drug development in a faster and more efficient...
6.
Tyrkalska S, Candel S, Pedoto A, Garcia-Moreno D, Alcaraz-Perez F, Sanchez-Ferrer A, et al.
FEMS Microbiol Rev
. 2022 Nov;
47(1).
PMID: 36323404
Although COVID-19 has only recently appeared, research studies have already developed and implemented many animal models for deciphering the secrets of the disease and provided insights into the biology of...
7.
Hernandez-Silva D, Canton-Sandoval J, Martinez-Navarro F, Perez-Sanchez H, de Oliveira S, Mulero V, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142384
Telomere shortening is the main molecular mechanism of aging, but not the only one. The adaptive immune system also ages, and older organisms tend to develop a chronic pro-inflammatory status...
8.
Garcia-Castillo J, Alcaraz-Perez F, Martinez-Balsalobre E, Garcia-Moreno D, Rossmann M, Fernandez-Lajarin M, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(32).
PMID: 34353901
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition syndrome caused by mutations in telomerase or telomeric proteins. Here, we report that zebrafish telomerase RNA ()...
9.
Bernabe-Garcia M, Martinez-Balsalobre E, Garcia-Moreno D, Garcia-Castillo J, Revilla-Nuin B, Blanco-Alcaina E, et al.
Mol Oncol
. 2021 Mar;
15(7):1818-1834.
PMID: 33713376
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere-independent functions of human TERT have been described. In this study, we report...
10.
Tyrkalska S, Perez-Oliva A, Rodriguez-Ruiz L, Martinez-Morcillo F, Alcaraz-Perez F, Martinez-Navarro F, et al.
Immunity
. 2019 Jun;
51(1):50-63.e5.
PMID: 31174991
Chronic inflammatory diseases are associated with altered hematopoiesis that could result in neutrophilia and anemia. Here we report that genetic or chemical manipulation of different inflammasome components altered the differentiation...