Francine Deschesnes
Overview
Explore the profile of Francine Deschesnes including associated specialties, affiliations and a list of published articles.
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10
Citations
243
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Recent Articles
1.
Boulay M, Pruneau-Pomerleau C, Villeneuve H, Deschesnes F, Ringuette L, Boulet L
J Asthma
. 2017 Oct;
55(3):231-243.
PMID: 29020468
Background: A "frequent exacerbator phenotype" has been described, mostly in the population of patients with severe asthma. Further data are needed on such exacerbation-prone patients in milder asthma. Aim: To...
2.
Boulet L, Robitaille C, Deschesnes F, Villeneuve H, Boulay M
Chest
. 2017 Sep;
152(6):1203-1213.
PMID: 28941741
Background: Asthma seems to present in the elderly as a specific phenotype that remains to be further described. In this prospective observational study, we aimed to assess the multidimensional aspects...
3.
Gauvreau G, Boulet L, Leigh R, Cockcroft D, Killian K, Davis B, et al.
Am J Respir Crit Care Med
. 2014 Dec;
191(2):161-7.
PMID: 25473939
Rationale: Effective antiinflammatory therapies are needed for the treatment of asthma, but preferably without the systemic adverse effects of glucocorticosteroids. Objectives: We evaluated the effect of an inhaled nonsteroidal glucocorticoid...
4.
Gauvreau G, Boulet L, Schmid-Wirlitsch C, Cote J, Duong M, Killian K, et al.
Respir Res
. 2011 Oct;
12:140.
PMID: 22029856
Background: Phosphodiesterase 4 (PDE4) inhibitors increase intracellular cyclic adenosine monophosphate (cAMP), leading to regulation of inflammatory cell functions. Roflumilast is a potent and targeted PDE4 inhibitor. The objective of this...
5.
Gauvreau G, Boulet L, Cockcroft D, FitzGerald J, Carlsten C, Davis B, et al.
Am J Respir Crit Care Med
. 2010 Nov;
183(8):1007-14.
PMID: 21057005
Rationale: Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1) antibodies that bind to different epitopes and...
6.
Boulet L, Deschesnes F, Chaboillez S, Lemiere C
Open Respir Med J
. 2010 Aug;
4:51-7.
PMID: 20802810
Rationale: A reduced response to inhaled corticosteroids (ICS) has been reported in smoking asthmatic patients but the effects of other medications remain to be evaluated in this population. Subjects And...
7.
Gauvreau G, Boulet L, Cockcroft D, Baatjes A, Cote J, Deschesnes F, et al.
Am J Respir Crit Care Med
. 2008 Feb;
177(9):952-8.
PMID: 18244953
Rationale: The drug product TPI ASM8 contains two modified phosphorothioate antisense oligonucleotides designed to inhibit allergic inflammation by down-regulating human CCR3 and the common beta chain (beta(c)) of IL-3, IL-5,...
8.
Boulet L, Lemiere C, Archambault F, Carrier G, Descary M, Deschesnes F
Chest
. 2006 Mar;
129(3):661-8.
PMID: 16537865
Smoking may influence the type of airway inflammation observed in asthma and its response to therapy. More studies are needed on how smoking-induced changes in lung function/structure and airway inflammation...
9.
Gauvreau G, Boulet L, Postma D, Kawayama T, Watson R, Duong M, et al.
J Allergy Clin Immunol
. 2005 Aug;
116(2):285-91.
PMID: 16083781
Background: Inhalation of allergens by sensitized patients with asthma induces reversible airway obstruction, airway hyperresponsiveness, and eosinophilic airway inflammation. Attenuation of allergen-induced bronchoconstriction and inflammation has been used to examine...
10.
Boulay M, Prince P, Deschesnes F, Chakir J, Boulet L
Respiration
. 2004 May;
71(3):216-24.
PMID: 15133340
Background: Asthma is characterized by airway inflammation and remodeling in which matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP) play an important role. Allergen exposure activates the inflammatory/repair process...