Francesca Gugliesi
Overview
Explore the profile of Francesca Gugliesi including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
495
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Recent Articles
1.
Targeting Peptidylarginine Deiminase 3 to Efficiently Suppress Herpes Simplex Virus Type 2 Infection
Pasquero S, Gugliesi F, Biolatti M, Albano C, Bajetto G, Trifiro L, et al.
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201398
Protein expression is regulated through multiple mechanisms, including post-translational modifications (PTMs), which can alter protein structure, stability, localization, and function. Among these, citrullination stands out due to its ability to...
2.
Albano C, Biolatti M, Mazibrada J, Pasquero S, Gugliesi F, Lo Cigno I, et al.
Front Cell Infect Microbiol
. 2024 Mar;
14:1359367.
PMID: 38529474
Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in...
3.
Bajetto G, Arnodo D, Biolatti M, Trifiro L, Albano C, Pasquero S, et al.
Microorganisms
. 2024 Feb;
12(2).
PMID: 38399777
The rise of drug resistance to antivirals poses a significant global concern for public health; therefore, there is a pressing need to identify novel compounds that can effectively counteract strains...
4.
Pasquero S, Gugliesi F, Biolatti M, DellOste V, Albano C, Bajetto G, et al.
PLoS Pathog
. 2023 Dec;
19(12):e1011849.
PMID: 38055760
Herpes simplex virus 1 (HSV-1) is a neurotropic virus that remains latent in neuronal cell bodies but reactivates throughout an individual's life, causing severe adverse reactions, such as herpes simplex...
5.
Biolatti M, Blangetti M, Baggieri M, Marchi A, Gioacchini S, Bajetto G, et al.
ACS Infect Dis
. 2023 Jun;
9(7):1310-1318.
PMID: 37358826
The current SARS-CoV-2 pandemic and the likelihood that new coronavirus strains will emerge in the immediate future point out the urgent need to identify new pan-coronavirus inhibitors. Strigolactones (SLs) are...
6.
Griffante G, Hewelt-Belka W, Albano C, Gugliesi F, Pasquero S, Castillo Pacheco S, et al.
mBio
. 2022 Apr;
13(3):e0043522.
PMID: 35420480
Cellular lipid metabolism plays a pivotal role in human cytomegalovirus (HCMV) infection, as increased lipogenesis in HCMV-infected cells favors the envelopment of newly synthesized viral particles. As all cells are...
7.
Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2
Pasquero S, Gugliesi F, Griffante G, DellOste V, Biolatti M, Albano C, et al.
Antiviral Res
. 2022 Mar;
200:105278.
PMID: 35288208
The current SARS-CoV-2 pandemic, along with the likelihood that new coronavirus strains will appear in the nearby future, highlights the urgent need to develop new effective antiviral agents. In this...
8.
Griffante G, Gugliesi F, Pasquero S, DellOste V, Biolatti M, Salinger A, et al.
Nat Commun
. 2021 Jun;
12(1):3910.
PMID: 34162877
Citrullination is the conversion of arginine-to-citrulline by protein arginine deiminases (PADs), whose dysregulation is implicated in the pathogenesis of various types of cancers and autoimmune diseases. Consistent with the ability...
9.
Riva G, Albano C, Gugliesi F, Pasquero S, Castillo Pacheco S, Pecorari G, et al.
Int J Mol Sci
. 2021 Feb;
22(3).
PMID: 33573337
Besides smoking and alcohol, human papillomavirus (HPV) is a factor promoting head and neck squamous cell carcinoma (HNSCC). In some human tumors, including HNSCC, a number of mutations are caused...
10.
Gugliesi F, Pasquero S, Griffante G, Scutera S, Albano C, Castillo Pacheco S, et al.
Viruses
. 2021 Feb;
13(2).
PMID: 33567734
Human cytomegalovirus (HCMV) is a ubiquitous double-stranded DNA virus belonging to the β-subgroup of the herpesvirus family. After the initial infection, the virus establishes latency in poorly differentiated myeloid precursors...