HPV Meets APOBEC: New Players in Head and Neck Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Feb 12

PMID 33573337

Citations 21

Authors

Giuseppe Riva

Camilla Albano

Francesca Gugliesi

Selina Pasquero

Sergio Fernando Castillo Pacheco

Giancarlo Pecorari

Santo Landolfo

Matteo Biolatti

Valentina DellOste

Affiliations

Soon will be listed here.

Abstract

Besides smoking and alcohol, human papillomavirus (HPV) is a factor promoting head and neck squamous cell carcinoma (HNSCC). In some human tumors, including HNSCC, a number of mutations are caused by aberrantly activated DNA-modifying enzymes, such as the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family of cytidine deaminases. As the enzymatic activity of APOBEC proteins contributes to the innate immune response to viruses, including HPV, the role of APOBEC proteins in HPV-driven head and neck carcinogenesis has recently gained increasing attention. Ongoing research efforts take the cue from two key observations: (1) APOBEC expression depends on HPV infection status in HNSCC; and (2) APOBEC activity plays a major role in HPV-positive HNSCC mutagenesis. This review focuses on recent advances on the role of APOBEC proteins in HPV-positive vs. HPV-negative HNSCC.

Citing Articles

HPV Infection and Oral Microbiota: Interactions and Future Implications.

Xia Q, Pierson S Int J Mol Sci. 2025; 26(4).

PMID: 40003891 PMC: 11855562. DOI: 10.3390/ijms26041424.

Viral infection, APOBEC3 dysregulation, and cancer.

Lehle J, Soleimanpour M, Mokhtari S, Ebrahimi D Front Genet. 2025; 15:1489324.

PMID: 39764440 PMC: 11701051. DOI: 10.3389/fgene.2024.1489324.

Spatial immune heterogeneity in a mouse tumor model after immunotherapy.

Smahel M, Johari S, Smahelova J, Pfeiferova L, Nunvar J Cancer Sci. 2024; 116(3):622-632.

PMID: 39624899 PMC: 11875765. DOI: 10.1111/cas.16421.

Temporal evolution and inter-patient heterogeneity in primary and recurrent head and neck squamous cell carcinoma.

Bresadola L, Weber D, Ritzel C, Lower M, Bukur V, Akilli-Ozturk O BJC Rep. 2024; 2(1):62.

PMID: 39516649 PMC: 11524138. DOI: 10.1038/s44276-024-00091-5.

Identification of hub genes and key modules in laryngeal squamous cell carcinoma.

Li H, Bo S, Guo Y, Wang T, Pan Y Transl Cancer Res. 2024; 13(7):3771-3782.

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