Francesca Grisoni
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Explore the profile of Francesca Grisoni including associated specialties, affiliations and a list of published articles.
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66
Citations
1046
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Recent Articles
11.
Boldini D, Ballabio D, Consonni V, Todeschini R, Grisoni F, Sieber S
J Cheminform
. 2024 Mar;
16(1):35.
PMID: 38528548
Natural products are a diverse class of compounds with promising biological properties, such as high potency and excellent selectivity. However, they have different structural motifs than typical drug-like compounds, e.g.,...
12.
van Tilborg D, Alenicheva A, Grisoni F
J Chem Inf Model
. 2023 Oct;
64(24):9643-9648.
PMID: 37851546
No abstract available.
13.
Mullowney M, Duncan K, Elsayed S, Garg N, van der Hooft J, Martin N, et al.
Nat Rev Drug Discov
. 2023 Sep;
22(11):895-916.
PMID: 37697042
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as...
14.
Boldini D, Grisoni F, Kuhn D, Friedrich L, Sieber S
J Cheminform
. 2023 Aug;
15(1):73.
PMID: 37641120
Decision tree ensembles are among the most robust, high-performing and computationally efficient machine learning approaches for quantitative structure-activity relationship (QSAR) modeling. Among them, gradient boosting has recently garnered particular attention,...
15.
Ballarotto M, Willems S, Stiller T, Nawa F, Marschner J, Grisoni F, et al.
J Med Chem
. 2023 May;
66(12):8170-8177.
PMID: 37256819
Generative neural networks trained on SMILES can design innovative bioactive molecules . These so-called chemical language models (CLMs) have typically been trained on tens of template molecules for fine-tuning. However,...
16.
Deckers J, Anbergen T, Hokke A, de Dreu A, Schrijver D, de Bruin K, et al.
Nat Rev Bioeng
. 2023 Apr;
1(4):286-303.
PMID: 37064653
Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short...
17.
Ortiz-Perez A, Izquierdo-Lozano C, Meijers R, Grisoni F, Albertazzi L
Nanoscale Adv
. 2023 Apr;
5(8):2307-2317.
PMID: 37056621
Barcoding of nano- and micro-particles allows distinguishing multiple targets at the same time within a complex mixture and is emerging as a powerful tool to increase the throughput of many...
18.
van Tilborg D, Alenicheva A, Grisoni F
J Chem Inf Model
. 2023 Mar;
63(7):2266.
PMID: 36995229
No abstract available.
19.
Grisoni F
Curr Opin Struct Biol
. 2023 Feb;
79:102527.
PMID: 36738564
Generative deep learning is accelerating de novo drug design, by allowing the generation of molecules with desired properties on demand. Chemical language models - which generate new molecules in the...
20.
Leveraging molecular structure and bioactivity with chemical language models for de novo drug design
Moret M, Pachon Angona I, Cotos L, Yan S, Atz K, Brunner C, et al.
Nat Commun
. 2023 Jan;
14(1):114.
PMID: 36611029
Generative chemical language models (CLMs) can be used for de novo molecular structure generation by learning from a textual representation of molecules. Here, we show that hybrid CLMs can additionally...