Francesca Dionisio
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Explore the profile of Francesca Dionisio including associated specialties, affiliations and a list of published articles.
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17
Citations
1195
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Recent Articles
1.
Calabria A, Spinozzi G, Cesana D, Buscaroli E, Benedicenti F, Pais G, et al.
Nature
. 2024 Oct;
636(8041):162-171.
PMID: 39442556
Haematopoietic stem cell (HSC) gene therapy (GT) may provide lifelong reconstitution of the haematopoietic system with gene-corrected cells. However, the effects of underlying genetic diseases, replication stress and ageing on...
2.
Cesana D, Cicalese M, Calabria A, Merli P, Caruso R, Volpin M, et al.
Nat Commun
. 2024 Apr;
15(1):3662.
PMID: 38688902
Hematopoietic stem cell gene therapy (GT) using a γ-retroviral vector (γ-RV) is an effective treatment for Severe Combined Immunodeficiency due to Adenosine Deaminase deficiency. Here, we describe a case of...
3.
Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis
Quaranta P, Basso-Ricci L, Hernandez R, Pacini G, Naldini M, Barcella M, et al.
Blood
. 2024 Mar;
143(19):1937-1952.
PMID: 38446574
In physiological conditions, few circulating hematopoietic stem/progenitor cells (cHSPCs) are present in the peripheral blood, but their contribution to human hematopoiesis remain unsolved. By integrating advanced immunophenotyping, single-cell transcriptional and...
4.
Migliavacca M, Barzaghi F, Fossati C, Rancoita P, Gabaldo M, Dionisio F, et al.
Nat Med
. 2024 Feb;
30(2):488-497.
PMID: 38355973
Adenosine deaminase (ADA) deficiency leads to severe combined immunodeficiency (SCID). Previous clinical trials showed that autologous CD34 cell gene therapy (GT) following busulfan reduced-intensity conditioning is a promising therapeutic approach...
5.
Scala S, Ferrua F, Basso-Ricci L, Dionisio F, Omrani M, Quaranta P, et al.
Nat Commun
. 2023 May;
14(1):3068.
PMID: 37244942
Mobilized peripheral blood is increasingly used instead of bone marrow as a source of autologous hematopoietic stem/progenitor cells for ex vivo gene therapy. Here, we present an unplanned exploratory analysis...
6.
Milardi G, Lorenzo B, Gerosa J, Barzaghi F, Di Matteo G, Omrani M, et al.
Eur J Immunol
. 2022 May;
52(7):1171-1189.
PMID: 35562849
Common variable immunodeficiency (CVID) is the most frequent primary antibody deficiency whereby follicular helper T (Tfh) cells fail to establish productive responses with B cells in germinal centers. Here, we...
7.
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
Cenciarelli S, Calbi V, Barzaghi F, Bernardo M, Oltolini C, Migliavacca M, et al.
Front Immunol
. 2020 Dec;
11:603428.
PMID: 33329599
In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment...
8.
Ferrua F, Cicalese M, Galimberti S, Giannelli S, Dionisio F, Barzaghi F, et al.
Lancet Haematol
. 2019 Apr;
6(5):e239-e253.
PMID: 30981783
Background: Wiskott-Aldrich syndrome is a rare, life-threatening, X-linked primary immunodeficiency characterised by microthrombocytopenia, infections, eczema, autoimmunity, and malignant disease. Lentiviral vector-mediated haemopoietic stem/progenitor cell (HSPC) gene therapy is a potentially...
9.
Scala S, Basso-Ricci L, Dionisio F, Pellin D, Giannelli S, Salerio F, et al.
Nat Med
. 2018 Oct;
24(11):1683-1690.
PMID: 30275570
Hematopoietic stem and progenitor cells (HSPC) are endowed with the role of generating and maintaining lifelong the extremely diverse pool of blood cells. Clinically, transplantation of human HSPC from an...
10.
Brigida I, Zoccolillo M, Cicalese M, Pfajfer L, Barzaghi F, Scala S, et al.
Blood
. 2018 Sep;
132(22):2362-2374.
PMID: 30254128
ARPC1B is a key factor for the assembly and maintenance of the ARP2/3 complex that is involved in actin branching from an existing filament. Germline biallelic mutations in have been...