Frances Connor
Overview
Explore the profile of Frances Connor including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
903
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Recent Articles
1.
Azzarelli R, Gillen S, Connor F, Lundie-Brown J, Puletti F, Drummond R, et al.
Development
. 2024 Nov;
151(24).
PMID: 39575884
The proneural transcription factor ASCL1 regulates neurogenesis and drives somatic cell reprogramming into neurons. However, not all cell types can be reprogrammed by ASCL1, raising the questions of what provides...
2.
Anderson C, Talmane L, Luft J, Connelly J, Nicholson M, Verburg J, et al.
Nature
. 2024 Jun;
630(8017):744-751.
PMID: 38867042
DNA base damage is a major source of oncogenic mutations. Such damage can produce strand-phased mutation patterns and multiallelic variation through the process of lesion segregation. Here we exploited these...
3.
Connor F, Salvatore S, DAuria E, Baldassarre M, Acunzo M, Di Bella G, et al.
Nutrients
. 2022 Mar;
14(6).
PMID: 35334974
Constipation is a very common disorder, mostly functional in nature, that may persist for years in up to 35-52% of children. Food allergy prevalence, severity and persistence are increasing over...
4.
Aitken S, Anderson C, Connor F, Pich O, Sundaram V, Feig C, et al.
Nature
. 2020 Jun;
583(7815):265-270.
PMID: 32581361
Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair...
5.
Connor F, Rayner T, Aitken S, Feig C, Lukk M, Santoyo-Lopez J, et al.
J Hepatol
. 2018 Jul;
69(4):840-850.
PMID: 29958939
Background & Aims: Carcinogen-induced mouse models of liver cancer are used extensively to study the pathogenesis of the disease and are critical for validating candidate therapeutics. These models can recapitulate...
6.
Singh H, Connor F
Aust J Gen Pract
. 2018 May;
47(5):273-277.
PMID: 29779292
Background: Constipation affects 5-30% of children and is responsible for 3% of primary care visits. General practitioners (GPs) are frequently the first medical encounter for concerned parents regarding their child's...
7.
Wong E, Schmitt B, Kazachenka A, Thybert D, Redmond A, Connor F, et al.
Nat Commun
. 2017 Oct;
8(1):1092.
PMID: 29061983
Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors between...
8.
Martinez-Jimenez C, Eling N, Chen H, Vallejos C, Kolodziejczyk A, Connor F, et al.
Science
. 2017 Apr;
355(6332):1433-1436.
PMID: 28360329
Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA...
9.
Ernst C, Pike J, Aitken S, Long H, Eling N, Stojic L, et al.
Elife
. 2016 Nov;
5.
PMID: 27855777
Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal...
10.
Sherman M, Yu R, Engle D, Ding N, Atkins A, Tiriac H, et al.
Cell
. 2014 Sep;
159(1):80-93.
PMID: 25259922
The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of quiescent to activated pancreatic stellate cells (PSCs) drives the...