Florian Bellutti
Overview
Explore the profile of Florian Bellutti including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
316
Followers
0
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Recent Articles
1.
Scheiblecker L, Klampfl T, Doma E, Nebenfuehr S, Torres-Quesada O, Strich S, et al.
Cell Death Dis
. 2025 Feb;
16(1):107.
PMID: 39966356
Metabolic reprogramming and cell cycle deregulation are hallmarks of cancer cells. The cell cycle kinase CDK6 has recently been implicated in a wide range of hematopoietic malignancies. We here investigate...
2.
Rizzotto D, Vigorito V, Rieder P, Gallob F, Moretta G, Soratroi C, et al.
Sci Adv
. 2024 Oct;
10(44):eado6607.
PMID: 39475598
Centrosomes are membrane-less organelles that orchestrate a wide array of biological functions by acting as microtubule organizing centers. Here, we report that caspase-2-driven apoptosis is elicited in blood cells failing...
3.
Trifinopoulos J, List J, Klampfl T, Klein K, Prchal-Murphy M, Witalisz-Siepracka A, et al.
Haematologica
. 2024 Oct;
PMID: 39385738
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of...
4.
Heller G, Nebenfuehr S, Bellutti F, Unal H, Zojer M, Scheiblecker L, et al.
iScience
. 2020 Nov;
23(10):101602.
PMID: 33205015
CDK6 is frequently overexpressed in various cancer types and functions as a positive regulator of the cell cycle and as a coregulator of gene transcription. We provide evidence that CDK6...
5.
Kollmann K, Briand C, Bellutti F, Schicher N, Blunder S, Zojer M, et al.
Oncotarget
. 2019 Mar;
10(14):1346-1359.
PMID: 30858922
The cyclin-dependent kinases CDK4 and CDK6 promote progression through the cell cycle, where their functions are considered to be redundant. Recent studies have identified an additional role for CDK6 in...
6.
Nebenfuehr S, Bellutti F, Sexl V
Mol Cell Oncol
. 2018 Sep;
5(5):e1511206.
PMID: 30263948
In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a...
7.
Bellutti F, Tigan A, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, et al.
Cancer Discov
. 2018 Jun;
8(7):884-897.
PMID: 29899063
Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by...
8.
Uras I, Bellutti F, Sexl V
Haematologica
. 2017 Aug;
102(8):1299-1301.
PMID: 28760806
No abstract available.
9.
Uras I, Walter G, Scheicher R, Bellutti F, Prchal-Murphy M, Tigan A, et al.
Blood
. 2016 Apr;
127(23):2890-902.
PMID: 27099147
Up to 30% of patients with acute myeloid leukemia have constitutively activating internal tandem duplications (ITDs) of the FLT3 receptor tyrosine kinase. Such mutations are associated with a poor prognosis...
10.
Bellutti F, Kauer M, Kneidinger D, Lion T, Klein R
J Virol
. 2014 Nov;
89(3):1608-27.
PMID: 25410853
Unlabelled: Adenoviruses encode a set of highly abundant microRNAs (mivaRNAs), which are generated by Dicer-mediated cleavage of the larger noncoding virus-associated RNAs (VA RNAs) I and II. We performed deep...