Florian Aeschimann
Overview
Explore the profile of Florian Aeschimann including associated specialties, affiliations and a list of published articles.
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15
Citations
683
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Recent Articles
1.
Pugliano C, Berger M, Ray R, Sapkos K, Wu B, Laird A, et al.
Mol Ther Methods Clin Dev
. 2025 Feb;
32(3):101297.
PMID: 40012884
Targeted gene editing to restore CD40L expression via homology-directed repair (HDR) in CD34 hematopoietic stem and progenitor cells (HSPCs) represents a potential long-term therapy for X-linked hyper IgM syndrome. However,...
2.
Cullot G, Aird E, Schlapansky M, Yeh C, van de Venn L, Vykhlyantseva I, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39604565
The DNA-PKcs inhibitor AZD7648 enhances CRISPR-Cas9-directed homology-directed repair efficiencies, with potential for clinical utility, but its possible on-target consequences are unknown. We found that genome editing with AZD7648 causes frequent...
3.
Zeglinski K, Montellese C, Ritchie M, Alhamdoosh M, Vonarburg C, Bowden R, et al.
Genome Res
. 2024 Oct;
34(11):1966-1975.
PMID: 39467647
Despite recent advances made toward improving the efficacy of lentiviral gene therapies, a sizeable proportion of produced vector contains an incomplete and thus potentially nonfunctional RNA genome. This can undermine...
4.
Mattout A, Gaidatzis D, Padeken J, Schmid C, Aeschimann F, Kalck V, et al.
Nat Cell Biol
. 2020 Apr;
22(5):579-590.
PMID: 32251399
In fission yeast and plants, RNA processing and degradation contribute to heterochromatin silencing, alongside conserved pathways of transcriptional repression. It has not been known whether similar pathways exist in metazoans....
5.
Azzi C, Aeschimann F, Neagu A, Grosshans H
Elife
. 2020 Apr;
9.
PMID: 32223899
Robust organismal development relies on temporal coordination of disparate physiological processes. In , the heterochronic pathway controls a timely juvenile-to-adult (J/A) transition. This regulatory cascade of conserved proteins and small...
6.
Aeschimann F, Neagu A, Rausch M, Grosshans H
Life Sci Alliance
. 2019 Mar;
2(2).
PMID: 30910805
The juvenile-to-adult (J/A) transition, or puberty, is a period of extensive changes of animal body morphology and function. The onset of puberty is genetically controlled, and the miRNA temporally regulates...
7.
Pereira L, Aeschimann F, Wang C, Lawson H, Serrano-Saiz E, Portman D, et al.
Elife
. 2019 Jan;
8.
PMID: 30599092
The molecular mechanisms that control the timing of sexual differentiation in the brain are poorly understood. We found that the timing of sexually dimorphic differentiation of postmitotic, sex-shared neurons in...
8.
Kumari P, Aeschimann F, Gaidatzis D, Keusch J, Ghosh P, Neagu A, et al.
Nat Commun
. 2018 Apr;
9(1):1549.
PMID: 29674686
RNA-binding proteins regulate all aspects of RNA metabolism. Their association with RNA is mediated by RNA-binding domains, of which many remain uncharacterized. A recently reported example is the NHL domain,...
9.
Masliah G, Maris C, Konig S, Yulikov M, Aeschimann F, Malinowska A, et al.
EMBO J
. 2018 Feb;
37(6).
PMID: 29449323
The accurate cleavage of pre-micro(mi)RNAs by Dicer and mi/siRNA guide strand selection are important steps in forming the RNA-induced silencing complex (RISC). The role of Dicer binding partner TRBP in...
10.
Mittal N, Guimaraes J, Gross T, Schmidt A, Vina-Vilaseca A, Nedialkova D, et al.
Nat Commun
. 2017 Sep;
8(1):457.
PMID: 28878244
In Saccharomyces cerevisiae, deletion of large ribosomal subunit protein-encoding genes increases the replicative lifespan in a Gcn4-dependent manner. However, how Gcn4, a key transcriptional activator of amino acid biosynthesis genes,...