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Florian A Rosenberger

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Articles 13
Citations 214
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Recent Articles
1.
El Fissi N, Rosenberger F, Chang K, Wilhalm A, Barton-Owen T, Hansen F, et al.
Nat Commun . 2024 Dec; 15(1):10719. PMID: 39715749
Aberration of mitochondrial function is a shared feature of many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics of the mitochondrial network. While some...
2.
Nordmann T, Anderton H, Hasegawa A, Schweizer L, Zhang P, Stadler P, et al.
Nature . 2024 Oct; 635(8040):1001-1009. PMID: 39415009
Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common medications and is an emerging public health issue. Patients with TEN undergo severe and sudden epidermal detachment...
3.
Kabatnik S, Post F, Drici L, Bartels A, Strauss M, Zheng X, et al.
iScience . 2024 Sep; 27(9):110620. PMID: 39252972
Colorectal adenomas (CRAs) are potential precursor lesions to adenocarcinomas, currently classified by morphological features. We aimed to establish a molecular feature-based risk allocation framework toward improved patient stratification. Deep visual...
4.
Thielert M, Weiss C, Mann M, Rosenberger F
Methods Mol Biol . 2024 Jun; 2817:97-113. PMID: 38907150
Spatially resolved mass spectrometry-based proteomics at single-cell resolution promises to provide insights into biological heterogeneity. We describe a protocol based on multiplexed data-independent acquisition (mDIA) with dimethyl labeling to enhance...
5.
Jiang S, Yuan T, Rosenberger F, Mourier A, Dragano N, Kremer L, et al.
Nat Metab . 2024 Apr; 6(6):1024-1035. PMID: 38689023
The oxidative phosphorylation system in mammalian mitochondria plays a key role in transducing energy from ingested nutrients. Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabolic and...
6.
Schweizer L, Krishnan R, Shimizu A, Metousis A, Kenny H, Mendoza R, et al.
medRxiv . 2023 Nov; PMID: 38014221
Serous borderline tumors (SBT) are epithelial neoplastic lesions of the ovaries that commonly have a good prognosis. In 10-15% of cases, however, SBT will recur as low-grade serous cancer (LGSC),...
7.
Rosenberger F, Thielert M, Strauss M, Schweizer L, Ammar C, Madler S, et al.
Nat Methods . 2023 Oct; 20(10):1530-1536. PMID: 37783884
Single-cell proteomics by mass spectrometry is emerging as a powerful and unbiased method for the characterization of biological heterogeneity. So far, it has been limited to cultured cells, whereas an...
8.
Nordmann T, Schweizer L, Metousis A, Thielert M, Rodriguez E, Rahbek-Gjerdrum L, et al.
Mol Cell Proteomics . 2023 Sep; 22(10):100643. PMID: 37683827
Defining the molecular phenotype of single cells in situ is key for understanding tissue architecture in health and disease. Advanced imaging platforms have recently been joined by spatial omics technologies,...
9.
Thielert M, Itang E, Ammar C, Rosenberger F, Bludau I, Schweizer L, et al.
Mol Syst Biol . 2023 Aug; 19(9):e11503. PMID: 37602975
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we...
10.
Shalon D, Culver R, Grembi J, Folz J, Treit P, Shi H, et al.
Nature . 2023 May; 617(7961):581-591. PMID: 37165188
The spatiotemporal structure of the human microbiome, proteome and metabolome reflects and determines regional intestinal physiology and may have implications for disease. Yet, little is known about the distribution of...