Flavia Pernasetti
Overview
Explore the profile of Flavia Pernasetti including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
152
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0
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Recent Articles
1.
Liu S, Gu Y, Pascual B, Yan Z, Hallin M, Zhang C, et al.
Blood Adv
. 2018 Jan;
1(15):1088-1100.
PMID: 29296751
The chemokine receptor CXCR4 is highly expressed and associated with poor prognosis in multiple malignancies. Upon engagement by its ligand, CXCL12, CXCR4 triggers intracellular signaling pathways that control trafficking of...
2.
Zhang Y, Saavedra E, Tang R, Gu Y, Lappin P, Trajkovic D, et al.
Sci Rep
. 2017 Aug;
7(1):7305.
PMID: 28779088
The chemokine receptor CXCR4 mediates cell anchorage in the bone marrow (BM) microenvironment and is overexpressed in 25-30% of patients with acute myeloid leukemia (AML). Here we have shown that...
3.
Kashyap M, Amaya-Chanaga C, Kumar D, Simmons B, Huser N, Gu Y, et al.
J Hematol Oncol
. 2017 May;
10(1):112.
PMID: 28526063
Background: The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the...
4.
Freimark B, Clark D, Pernasetti F, Nickel J, Myszka D, Baeuerle P, et al.
Mol Immunol
. 2007 May;
44(15):3741-50.
PMID: 17507095
A humanized, affinity-matured IgG1 antibody, called D93, and its parental murine IgM HUI77 have been shown to specifically bind denatured collagens and thereby inhibit angiogenesis and tumor growth in various...
5.
Pernasetti F, Nickel J, Clark D, Baeuerle P, Van Epps D, Freimark B
Int J Oncol
. 2006 Nov;
29(6):1371-9.
PMID: 17088974
Matrix metalloproteases (MMPs) secreted by both tumor and endothelial cells proteolytically degrade collagen during tumor growth and neo-vascularization. This exposes cryptic binding sites on collagen with functional relevance for angiogenesis....
6.
Pernasetti F, Spady T, Hall S, Rosenberg S, Givens M, Anderson S, et al.
Mol Cell Endocrinol
. 2003 Jun;
203(1-2):169-83.
PMID: 12782413
Targeted tumorigenesis in transgenic mice has been a powerful tool for the study of gene expression and oncogenesis, as well as for the production of differentiated immortal cell lines from...
7.
Arroyo A, Pernasetti F, Vasilyev V, Amato P, Yen S, Mellon P
Clin Endocrinol (Oxf)
. 2002 Aug;
57(2):283-91.
PMID: 12153609
We report a 28-year-old-female who presented with primary amenorrhoea, absence of puberty, obesity and normal stature. The subject was clearly short as a child, with a height more than 2...
8.
Vasilyev V, Pernasetti F, Rosenberg S, Barsoum M, Austin D, Webster N, et al.
Endocrinology
. 2002 Apr;
143(5):1651-9.
PMID: 11956146
GnRH regulates gonadotrope cells through GnRH receptor activation of the PKC-, MAPK-, and calcium-activated signaling cascades. Due to the paucity of homologous model systems expressing FSHbeta, little is known about...