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Flavia Michelini

Explore the profile of Flavia Michelini including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 888
Followers 0
Related Specialties
Oncology
Biology
Cell Biology
Top 10 Co-Authors
Fabrizio dAdda di Fagagna
Sofia Francia
Bob T Li
Maurizio Scaltriti
Matteo Cabrini
Ubaldo Gioia
Sheeno Thyparambil
Sarat Chandarlapaty
Piero Carninci
Giuseppe Curigliano
Published In
Cancer Res
Aging Cell
Nature
Nat Cell Biol
Sci Rep
Affiliations
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Recent Articles
11.
RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci
Michelini F, Rossiello F, dAdda di Fagagna F, Francia S
Nat Protoc . 2019 Apr; 14(5):1489-1508. PMID: 30962605
Non-coding RNA (ncRNA) molecules have been shown to play a variety of cellular roles; however, the contributions of different types of RNA to specific phenomena are often hard to dissect....
12.
From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond
Michelini F, Jalihal A, Francia S, Meers C, Neeb Z, Rossiello F, et al.
Chem Rev . 2018 Mar; 118(8):4365-4403. PMID: 29600857
Coding for proteins has been considered the main function of RNA since the "central dogma" of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of...
13.
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, et al.
Nat Cell Biol . 2017 Nov; 19(12):1400-1411. PMID: 29180822
The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation. Here we show that...
14.
A damaged genome's transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
Iannelli F, Galbiati A, Capozzo I, Nguyen Q, Magnuson B, Michelini F, et al.
Nat Commun . 2017 Jun; 8:15656. PMID: 28561034
Of the many types of DNA damage, DNA double-strand breaks (DSBs) are probably the most deleterious. Mounting evidence points to an intricate relationship between DSBs and transcription. A cell system...
15.
Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1
De Luca G, Ventura I, Sanghez V, Russo M, Ajmone-Cat M, Cacci E, et al.
Aging Cell . 2013 May; 12(4):695-705. PMID: 23648059
The contribution that oxidative damage to DNA and/or RNA makes to the aging process remains undefined. In this study, we used the hMTH1-Tg mouse model to investigate how oxidative damage...
16.
Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence
Falcone G, Mazzola A, Michelini F, Bossi G, Censi F, Biferi M, et al.
Aging Cell . 2012 Nov; 12(2):312-5. PMID: 23167636
Senescence is thought to be triggered by DNA damage, usually indirectly assessed as activation of the DNA damage response (DDR), but direct surveys of genetic damage are lacking. Here, we...
17.
Site-specific DICER and DROSHA RNA products control the DNA-damage response
Francia S, Michelini F, Saxena A, Tang D, de Hoon M, Anelli V, et al.
Nature . 2012 Jun; 488(7410):231-5. PMID: 22722852
Non-coding RNAs (ncRNAs) are involved in an increasingly recognized number of cellular events. Some ncRNAs are processed by DICER and DROSHA RNases to give rise to small double-stranded RNAs involved...