Firat Kaya
Overview
Explore the profile of Firat Kaya including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
648
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Recent Articles
1.
Negatu D, Aragaw W, Gebresilase T, Paruchuri S, Kaya F, Shin S, et al.
Antimicrob Agents Chemother
. 2024 Nov;
69(1):e0104624.
PMID: 39565116
β-Lactams present several desirable pharmacodynamic features leading to the rapid eradication of many bacterial pathogens. Imipenem (IPM) and cefoxitin (FOX) are injectable β-lactams recommended during the intensive treatment phase of...
2.
Bauman A, Sarathy J, Kaya F, Massoudi L, Scherman M, Hastings C, et al.
Antimicrob Agents Chemother
. 2024 Sep;
68(11):e0071624.
PMID: 39345140
The spectinamides are novel, narrow-spectrum semisynthetic analogs of spectinomycin, modified to avoid intrinsic efflux by . Spectinamides, including lead MBX-4888A (Lee-1810), exhibit promising therapeutic profiles in mice, as single drugs...
3.
Hassoun Y, Aptekmann A, Keniya M, Gomez R, Alayo N, Novi G, et al.
PLoS Pathog
. 2024 Sep;
20(9):e1012521.
PMID: 39250486
Invasive fungal infections are associated with high mortality, which is exacerbated by the limited antifungal drug armamentarium and increasing antifungal drug resistance. Echinocandins are a frontline antifungal drug class targeting...
4.
Wasserman S, Antilus-Sainte R, Abdelgawad N, Odjourian N, Cristaldo M, Dougher M, et al.
Antimicrob Agents Chemother
. 2024 Jul;
68(8):e0078324.
PMID: 39028192
Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective...
5.
Bauman A, Sarathy J, Kaya F, Massoudi L, Scherman M, Hastings C, et al.
bioRxiv
. 2024 May;
PMID: 38798577
The spectinamides are novel, narrow-spectrum semisynthetic analogs of spectinomycin, modified to avoid intrinsic efflux by . Spectinamides, including lead MBX-4888A (Lee-1810), exhibit promising therapeutic profiles in mice, as single drugs...
6.
Boshoff H, Young K, Ahn Y, Yadav V, Crowley B, Yang L, et al.
ACS Infect Dis
. 2024 Apr;
10(5):1679-1695.
PMID: 38581700
Linezolid is a drug with proven human antitubercular activity whose use is limited to highly drug-resistant patients because of its toxicity. This toxicity is related to its mechanism of action─linezolid...
7.
Datta M, Via L, Dartois V, Weiner D, Zimmerman M, Kaya F, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(14):e2321336121.
PMID: 38530888
Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and implemented for immuno-modulation, other host targets-such as nonimmune stromal components...
8.
Lanni F, Antilus Sainte R, Hansen Jr M, Parigi P, Kaya F, LoMauro K, et al.
Antimicrob Agents Chemother
. 2023 Nov;
67(12):e0067123.
PMID: 37966227
Tuberculosis meningitis (TBM) is essentially treated with the first-line regimen used against pulmonary tuberculosis, with a prolonged continuation phase. However, clinical outcomes are poor in comparison, for reasons that are...
9.
Ramey M, Kaya F, Bauman A, Massoudi L, Sarathy J, Zimmerman M, et al.
Antimicrob Agents Chemother
. 2023 Oct;
67(11):e0059723.
PMID: 37791784
BTZ-043, a suicide inhibitor of the cell wall synthesis decaprenylphosphoryl-beta-D-ribose 2' epimerase, is under clinical development as a potential new anti-tuberculosis agent. BTZ-043 is potent and bactericidal but has limited...
10.
Walter N, Ernest J, Dide-Agossou C, Bauman A, Ramey M, Rossmassler K, et al.
Antimicrob Agents Chemother
. 2023 Aug;
67(9):e0028423.
PMID: 37565762
Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes...