Fiona Simpson
Overview
Explore the profile of Fiona Simpson including associated specialties, affiliations and a list of published articles.
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Articles
87
Citations
2314
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Recent Articles
1.
Wong J, McCulloch T, Alim L, Omer N, Mehdi A, Tuong Z, et al.
EBioMedicine
. 2024 May;
104:105176.
PMID: 38810560
Background: Natural killer (NK) cells are important innate immunity players and have unique abilities to recognize and eliminate cancer cells, particularly in settings of antibody-opsonization and antibody-dependant cellular cytotoxicity (ADCC)....
2.
Muraro E, Montico B, Lum B, Colizzi F, Giurato G, Salvati A, et al.
Front Immunol
. 2024 Mar;
15:1336566.
PMID: 38510242
Introduction: About 50% of cutaneous melanoma (CM) patients present activating BRAF mutations that can be effectively targeted by BRAF inhibitors (BRAFi). However, 20% of CM patients exhibit intrinsic drug resistance...
3.
Karlsen E, Walpole E, Simpson F
Curr Treat Options Oncol
. 2024 Jan;
25(3):275-283.
PMID: 38270799
Monoclonal antibody (mAb) therapy is now considered a main component of cancer therapy in Australia. Although traditionally thought of as pure signalling inhibitors, a large proponent of these medications function...
4.
Subasic C, Simpson F, Minchin R, Kaminskas L
Nanomedicine
. 2024 Jan;
56:102733.
PMID: 38199450
Anti-cancer monoclonal antibodies often fail to provide therapeutic benefit in receptor-positive patients due to rapid endocytosis of antibody-bound cell surface receptors. High dose co-administration of prochlorperazine (PCZ) inhibits endocytosis and...
5.
Wang P, Zhou R, Zhou R, Feng S, Zhao L, Li W, et al.
Redox Biol
. 2023 Dec;
69:102976.
PMID: 38052106
Cold atmospheric plasma (CAP) holds promise as a cancer-specific treatment that selectively kills various types of malignant cells. We used CAP-activated media (PAM) to utilize a range of the generated...
6.
de Lima P, Broit N, Huang J, Lim J, Gardiner D, Brown I, et al.
Front Oncol
. 2023 Sep;
13:1231104.
PMID: 37746297
Introduction: Cutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system. This metastatic process is called perineural invasion...
7.
Subasic C, Butcher N, Simpson F, Minchin R, Kaminskas L
Mol Pharm
. 2023 Aug;
20(9):4468-4477.
PMID: 37548597
Dynamin II (dynII) plays a significant role in the internalization pathways of endocytic cells, by allowing membrane invaginations to "bud off". An important class of dynII inhibitors that are used...
8.
Banushi B, Joseph S, Lum B, Lee J, Simpson F
Nat Rev Cancer
. 2023 May;
23(7):450-473.
PMID: 37217781
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the extracellular environment are packaged, sorted and internalized into cells. Endocytosis is also a mechanism of drug...
9.
Banushi B, Simpson F
Cells
. 2022 Nov;
11(22).
PMID: 36429129
Lysosome-related organelles (LROs) are a group of functionally diverse, cell type-specific compartments. LROs include melanosomes, alpha and dense granules, lytic granules, lamellar bodies and other compartments with distinct morphologies and...
10.
Wong J, Dolcetti R, Rhee H, Simpson F, Souza-Fonseca-Guimaraes F
Trends Cancer
. 2022 Nov;
9(2):111-121.
PMID: 36379852
Enhancing natural killer (NK) cell-based innate immunity has become a promising strategy for immunotherapy against hard-to-cure solid cancers. Monoclonal antibody (mAb) therapy has been used to activate NK-cell-mediated antibody-dependent cellular...