Filipa Marcelo
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Explore the profile of Filipa Marcelo including associated specialties, affiliations and a list of published articles.
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51
Citations
510
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Recent Articles
1.
Soares C, Laugieri M, Grosso A, Natale M, Coelho H, Behren S, et al.
JACS Au
. 2025 Jan;
5(1):225-236.
PMID: 39886580
The mucin -glycan sialyl Tn antigen (sTn, Neu5Acα2-6GalNAcα1--Ser/Thr) is an antigen associated with different types of cancers, often linked with a higher risk of metastasis and poor prognosis. Despite efforts...
2.
Silva Z, Soares C, Barbosa M, Palma A, Marcelo F, Videira P
Semin Immunol
. 2024 Oct;
74-75:101900.
PMID: 39461124
Dendritic cells (DCs) are crucial for initiating immune responses against tumours by presenting antigens to T cells. Glycosylation, particularly sialylation, plays a significant role in regulating cell functions, by modulating...
3.
van der Meijs N, Travecedo M, Marcelo F, van Vliet S
Expert Opin Ther Targets
. 2024 Jul;
28(7):601-612.
PMID: 38946482
Introduction: CLEC10A is a C-type lectin receptor that specifically marks the conventional dendritic cell subsets two and three (cDC2 and DC3). It has a unique recognition profile of glycan antigens,...
4.
Atxabal U, Nycholat C, Propster J, Fernandez A, Oyenarte I, Pia Lenza M, et al.
ACS Chem Biol
. 2024 Feb;
19(2):483-496.
PMID: 38321945
Human sialic-acid-binding immunoglobulin-like lectin-9 (Siglec-9) is a glycoimmune checkpoint receptor expressed on several immune cells. Binding of Siglec-9 to sialic acid containing glycans (sialoglycans) is well documented to modulate its...
5.
Bermejo I, Guerreiro A, Eguskiza A, Martinez-Saez N, Lazaris F, Asin A, et al.
JACS Au
. 2024 Jan;
4(1):150-163.
PMID: 38274250
Mucin-1 (MUC1) glycopeptides are exceptional candidates for potential cancer vaccines. However, their autoantigenic nature often results in a weak immune response. To overcome this drawback, we carefully engineered synthetic antigens...
6.
Pia Lenza M, Egia-Mendikute L, Antonana-Vildosola A, Soares C, Coelho H, Corzana F, et al.
Nat Commun
. 2023 Jun;
14(1):3496.
PMID: 37311743
Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging cancer immunotherapy target. However, limited understanding of its structure and mechanism of action restrains the development of drug...
7.
Pia Lenza M, Atxabal U, Nycholat C, Oyenarte I, Franconetti A, Quintana J, et al.
JACS Au
. 2023 Jan;
3(1):204-215.
PMID: 36711084
Human sialic acid binding immunoglobulin-like lectin-8 (Siglec-8) is an inhibitory receptor that triggers eosinophil apoptosis and can inhibit mast cell degranulation when engaged by specific monoclonal antibodies (mAbs) or sialylated...
8.
Gonzalez-Ramirez A, Grosso A, Yang Z, Companon I, Coelho H, Narimatsu Y, et al.
Nat Commun
. 2022 May;
13(1):2398.
PMID: 35504880
C1GalT1 is an essential inverting glycosyltransferase responsible for synthesizing the core 1 structure, a common precursor for mucin-type O-glycans found in many glycoproteins. To date, the structure of C1GalT1 and...
9.
Coelho H, Rivas M, Grosso A, Diniz A, Soares C, Francisco R, et al.
JACS Au
. 2022 Apr;
2(3):631-645.
PMID: 35373202
The large family of polypeptide GalNAc-transferases (GalNAc-Ts) controls with precision how GalNAc -glycans are added in the tandem repeat regions of mucins (, MUC1). However, the structural features behind the...
10.
Soares C, Grosso A, Ereno-Orbea J, Coelho H, Marcelo F
Front Mol Biosci
. 2021 Dec;
8:727847.
PMID: 34869580
All cells are decorated with a highly dense and complex structure of glycan chains, which are mostly attached to proteins and lipids. In this context, sialic acids are a family...