Filip Cuyckens
Overview
Explore the profile of Filip Cuyckens including associated specialties, affiliations and a list of published articles.
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Articles
76
Citations
750
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Recent Articles
1.
Flinders B, Huizing L, Singh B, Lim H, van Heerden M, Cuyckens F, et al.
J Am Soc Mass Spectrom
. 2025 Jan;
36(2):265-276.
PMID: 39824777
Drug toxicity during the development of candidate pharmaceuticals is the leading cause of discontinuation in preclinical drug discovery and development. Traditionally, the cause of the toxicity is often determined by...
2.
Leclercq L, de Vries R, Koppen V, Verboven P, Cuyckens F, Wynant I, et al.
Chem Res Toxicol
. 2024 Dec;
38(1):58-72.
PMID: 39662968
The β-amyloid precursor protein-cleaving enzyme 1 (BACE1) inhibitor JNJ-54861911, a candidate for the treatment of Alzheimer's disease, was withdrawn from clinical trials due to drug-induced liver injury (DILI). This paper...
3.
Dillen L, Deschrijver T, Van Mol K, Op de Beeck J, Jacobs P, Cuyckens F
Anal Sci Adv
. 2024 May;
2(7-8):354-363.
PMID: 38715959
Chromatographic analysis of therapeutic oligonucleotides is challenging due to the presence of closely related impurities, degradants or metabolites and due to the presence of phosphorothioate bonds, which introduce chiral centers....
4.
Cuyckens F, Hvenegaard M, Cassidy K, Spracklin D, James A, Pedersen M, et al.
Drug Metab Dispos
. 2024 Jan;
52(3):153-158.
PMID: 38216306
The administration of radiolabeled drug candidates is considered the gold standard in absorption, distribution, metabolism, and excretion studies for small-molecule drugs since it allows facile and accurate quantification of parent...
5.
Li W, Vazvaei-Smith F, Dear G, Boer J, Cuyckens F, Fraier D, et al.
Clin Pharmacol Ther
. 2023 Dec;
115(5):939-953.
PMID: 38073140
The intent of this perspective is to share the recommendations of the International Consortium for Innovation and Quality in Pharmaceutical Development Metabolite Bioanalysis Working Group on the fit-for-purpose metabolite bioanalysis...
6.
Young G, Spracklin D, James A, Hvenegaard M, Pedersen M, Wagner D, et al.
Clin Pharmacol Ther
. 2023 Nov;
115(5):931-938.
PMID: 38018358
A review of the use of microdoses and isotopic microtracers for clinical intravenous pharmacokinetic (i.v. PK) data provision is presented. The extent of application of the varied approaches available and...
7.
van Outersterp R, Oosterhout J, Gebhardt C, Berden G, Engelke U, Wevers R, et al.
Anal Chem
. 2023 Feb;
95(6):3406-3413.
PMID: 36735826
Infrared ion spectroscopy (IRIS) can be used to identify molecular structures detected in mass spectrometry (MS) experiments and has potential applications in a wide range of analytical fields. However, MS-based...
8.
Young G, Spracklin D, James A, Hvenegaard M, Scarfe G, Wagner D, et al.
Clin Pharmacol Ther
. 2022 Jun;
113(4):775-781.
PMID: 35733280
The human absorption, distribution, metabolism, and excretion (hADME) study is the cornerstone of the clinical pharmacology package for small molecule drugs, providing comprehensive information on the rates and routes of...
9.
Lagatie O, Njumbe Ediage E, Van Roosbroeck D, Van Asten S, Verheyen A, Debrah L, et al.
PLoS Negl Trop Dis
. 2021 Nov;
15(11):e0009999.
PMID: 34843471
The neglected tropical disease onchocerciasis, or river blindness, is caused by infection with the filarial nematode Onchocerca volvulus. Current estimates indicate that 17 million people are infected worldwide, the majority...
10.
van Outersterp R, Martens J, Peremans A, Lamard L, Cuyckens F, Oomens J, et al.
Analyst
. 2021 Nov;
146(23):7218-7229.
PMID: 34724520
Infrared ion spectroscopy is increasingly recognized as a method to identify mass spectrometry-detected analytes in many (bio)chemical areas and its integration in analytical laboratories is now on the horizon. Commercially...