Fereidoon Daryaee
Overview
Explore the profile of Fereidoon Daryaee including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
18
Citations
217
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Davoodi S, Daryaee F, Iuliano J, Tolentino Collado J, He Y, Pollard A, et al.
Biochemistry
. 2023 Jun;
62(12):1943-1952.
PMID: 37270808
InhA, the enoyl-ACP reductase, is a target for the tuberculosis (TB) drug isoniazid (INH). InhA inhibitors that do not require KatG activation avoid the most common mechanism of INH resistance,...
2.
Li Y, Lannigan W, Davoodi S, Daryaee F, Corrionero A, Alfonso P, et al.
J Med Chem
. 2023 May;
66(11):7454-7474.
PMID: 37195170
Bruton's tyrosine kinase (BTK) is a target for treating B-cell malignancies and autoimmune diseases, and several BTK inhibitors are already approved for use in humans. Heterobivalent BTK protein degraders are...
3.
Basak S, Li Y, Tao S, Daryaee F, Merino J, Gu C, et al.
J Med Chem
. 2022 Aug;
65(17):11854-11875.
PMID: 36037447
UDP-3--(-3-hydroxymyristoyl)--acetylglucosamine deacetylase (LpxC) is a promising drug target in Gram-negative bacteria. Previously, we described a correlation between the residence time of inhibitors on LpxC (LpxC) and the post-antibiotic effect (PAE)...
4.
Basu R, Wang N, Basak S, Daryaee F, Babar M, Allen E, et al.
ACS Infect Dis
. 2021 Aug;
7(9):2755-2763.
PMID: 34357770
The translation of time-dependent drug-target occupancy to extended pharmacological activity at low drug concentration depends on factors such as target vulnerability and the rate of target turnover. Previously, we demonstrated...
5.
Li Y, Daryaee F, Yoon G, Noh D, Smith-Jones P, Si Y, et al.
ACS Infect Dis
. 2020 Jul;
6(8):2249-2259.
PMID: 32672928
Deep-seated bacterial infections caused by pathogens such as are difficult to diagnose and treat and are thus a major threat to human health. In previous work we demonstrated that positron...
6.
Correlating Drug-Target Residence Time and Post-antibiotic Effect: Insight into Target Vulnerability
Davoodi S, Daryaee F, Chang A, Walker S, Tonge P
ACS Infect Dis
. 2020 Feb;
6(4):629-636.
PMID: 32011855
Target vulnerability correlates the level of drug-target engagement required to generate a pharmacological response. High vulnerability targets are those that require only a relatively small fraction of occupancy to achieve...
7.
Daryaee F, Tonge P
Curr Opin Chem Biol
. 2019 Apr;
50:120-127.
PMID: 31030171
Pharmacokinetic/pharmacodynamic (PK/PD) models predict the effect time course resulting from a drug dose. In this review, we summarize the development of mechanistic PK/PD models that explicitly integrate the kinetics of...
8.
Zhang Z, Ordonez A, Wang H, Li Y, Gogarty K, Weinstein E, et al.
ACS Infect Dis
. 2018 Aug;
4(11):1635-1644.
PMID: 30067329
Staphylococcus aureus is the leading cause of life-threatening infections, frequently originating from unknown or deep-seated foci. Source control and institution of appropriate antibiotics remain challenges, especially with infections due to...
9.
Daryaee F, Zhang Z, Gogarty K, Li Y, Merino J, Fisher S, et al.
Chem Sci
. 2017 May;
8(5):3434-3443.
PMID: 28507715
Correlating target engagement with drug activity remains a central challenge in efforts to improve the efficiency of drug discovery. Previously we described a mechanistic pharmacokinetic-pharmacodynamic (PK/PD) model that used drug-target...
10.
Neckles C, Eltschkner S, Cummings J, Hirschbeck M, Daryaee F, Bommineni G, et al.
Biochemistry
. 2017 Feb;
56(13):1865-1878.
PMID: 28225601
There is growing awareness of the link between drug-target residence time and in vivo drug activity, and there are increasing efforts to determine the molecular factors that control the lifetime...