Felix Nitschke
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Explore the profile of Felix Nitschke including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
433
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Recent Articles
1.
Nitschke S, Montalbano A, Whiting M, Smith B, Mukherjee-Roy N, Marchioni C, et al.
EMBO J
. 2025 Jan;
44(5):1379-1413.
PMID: 39806098
Polyglucosans are glycogen molecules with overlong chains, which are hyperphosphorylated in the neurodegenerative Lafora disease (LD). Brain polyglucosan bodies (PBs) cause fatal neurodegenerative diseases including Lafora disease and adult polyglucosan...
2.
Aisyah R, Ohshima N, Watanabe D, Nakagawa Y, Sakuma T, Nitschke F, et al.
Commun Biol
. 2024 May;
7(1):604.
PMID: 38769369
Glycerophosphocholine (GPC) is an important precursor for intracellular choline supply in phosphatidylcholine (PC) metabolism. GDE5/Gpcpd1 hydrolyzes GPC into choline and glycerol 3-phosphate; this study aimed to elucidate its physiological function...
3.
Mitra S, Chen B, Shelton J, Nitschke S, Wu J, Covington L, et al.
Acta Neuropathol
. 2024 Feb;
147(1):46.
PMID: 38411740
At least five enzymes including three E3 ubiquitin ligases are dedicated to glycogen's spherical structure. Absence of any reverts glycogen to a structure resembling amylopectin of the plant kingdom. This...
4.
Nitschke F, Montalbano A
Neurotherapeutics
. 2022 Oct;
19(6):1878-1882.
PMID: 36266502
No abstract available.
5.
Nitschke S, Sullivan M, Mitra S, Marchioni C, Lee J, Smith B, et al.
Brain
. 2022 Jan;
145(7):2361-2377.
PMID: 35084461
Longer glucan chains tend to precipitate. Glycogen, by far the largest mammalian glucan and the largest molecule in the cytosol with up to 55 000 glucoses, does not, due to...
6.
Wang L, Wang Y, Makhmoudova A, Nitschke F, Tetlow I, Emes M
Plant Physiol
. 2021 Dec;
188(4):1866-1886.
PMID: 34850950
Starch branching enzymes (SBEs) are one of the major classes of enzymes that catalyze starch biosynthesis in plants. Here, we utilized the clustered regularly interspaced short palindromic repeats-CRISPR associated protein...
7.
Ahonen S, Nitschke S, Grossman T, Kordasiewicz H, Wang P, Zhao X, et al.
Brain
. 2021 May;
144(10):2985-2993.
PMID: 33993268
Lafora disease is a fatal progressive myoclonus epilepsy. At root, it is due to constant acquisition of branches that are too long in a subgroup of glycogen molecules, leading them...
8.
Gumusgoz E, Guisso D, Kasiri S, Wu J, Dear M, Verhalen B, et al.
Neurotherapeutics
. 2021 Apr;
18(2):1414-1425.
PMID: 33830476
Many adult and most childhood neurological diseases have a genetic basis. CRISPR/Cas9 biotechnology holds great promise in neurological therapy, pending the clearance of major delivery, efficiency, and specificity hurdles. We...
9.
Impaired fear learning and extinction, but not generalization, in anxious and non-anxious depression
Wurst C, Schiele M, Stonawski S, Weiss C, Nitschke F, Hommers L, et al.
J Psychiatr Res
. 2021 Feb;
135:294-301.
PMID: 33524676
Fear conditioning and generalization are well-known mechanisms in the pathogenesis of anxiety disorders. Extinction of conditioned fear responses is crucial for the psychotherapeutic treatment of these diseases. Anxious depression as...
10.
Menke A, Nitschke F, Hellmuth A, Helmel J, Wurst C, Stonawski S, et al.
Brain Behav Immun
. 2021 Jan;
93:132-140.
PMID: 33422640
Childhood trauma as well as severe events occurring later in life have been associated with the development of major depressive disorder (MDD). However, the interaction of early and later occurring...