Felix J Metzner
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Explore the profile of Felix J Metzner including associated specialties, affiliations and a list of published articles.
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5
Citations
57
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Recent Articles
1.
Kugler M, Metzner F, Witte G, Hopfner K, Lammens K
Nat Commun
. 2024 Dec;
15(1):10500.
PMID: 39627193
Human Schlafen 11 (SLFN11) is sensitizing cells to DNA damaging agents by irreversibly blocking stalled replication forks, making it a potential predictive biomarker in chemotherapy. Furthermore, SLFN11 acts as a...
2.
Kunert F, Metzner F, Jung J, Hopfler M, Woike S, Schall K, et al.
Sci Adv
. 2022 Dec;
8(49):eadd3189.
PMID: 36490333
The nucleosomal landscape of chromatin depends on the concerted action of chromatin remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene regulatory elements, which is proposed to...
3.
Metzner F, Wenzl S, Kugler M, Krebs S, Hopfner K, Lammens K
Nat Commun
. 2022 Sep;
13(1):5464.
PMID: 36115853
Schlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA endoribonuclease and DNA binding functions. It is recruited to stalled replication forks in response to replication stress and inhibits...
4.
Metzner F, Huber E, Hopfner K, Lammens K
Nucleic Acids Res
. 2022 Jan;
50(2):1147-1161.
PMID: 35037067
The Schlafen family belongs to the interferon-stimulated genes and its members are involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair and tRNA processing. Here, we...
5.
Scheu A, Lim S, Metzner F, Mohammed S, Howarth M
Nat Commun
. 2021 Jan;
12(1):717.
PMID: 33514717
The Neisseria meningitidis protein FrpC contains a self-processing module (SPM) undergoing autoproteolysis via an aspartic anhydride. Herein, we establish NeissLock, using a binding protein genetically fused to SPM. Upon calcium...