Jia-Xuan Chen
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Explore the profile of Jia-Xuan Chen including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
435
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Recent Articles
1.
Hutten S, Chen J, Isaacs A, Dormann D
Biochemistry
. 2024 Aug;
63(17):2141-2152.
PMID: 39146246
Dipeptide repeat proteins (DPRs) are aberrant protein species found in C9orf72-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative diseases characterized by the cytoplasmic mislocalization and aggregation of...
2.
Schmidt A, Allmann S, Schwarzenbach C, Snyder P, Chen J, Nagel G, et al.
Nucleic Acids Res
. 2024 May;
52(12):6945-6963.
PMID: 38783095
Cellular senescence, a major driver of aging, can be stimulated by DNA damage, and is counteracted by the DNA repair machinery. Here we show that in p16INK4a-deficient cells, senescence induction...
3.
Dobert J, Bub S, Machtel R, Januliene D, Steger L, Regensburger M, et al.
Adv Sci (Weinh)
. 2024 Apr;
11(25):e2401641.
PMID: 38666485
Genetic variants of GBA1 can cause the lysosomal storage disorder Gaucher disease and are among the highest genetic risk factors for Parkinson's disease (PD). GBA1 encodes the lysosomal enzyme beta-glucocerebrosidase...
4.
Renz C, Asimaki E, Meister C, Albanese V, Petriukov K, Krapoth N, et al.
Mol Cell
. 2023 Dec;
84(2):386-400.e11.
PMID: 38103558
The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the experimental tools...
5.
Maus H, Gellert A, Englert O, Chen J, Schirmeister T, Barthels F
RSC Med Chem
. 2023 Nov;
14(11):2365-2379.
PMID: 37974966
Dengue virus (DENV) infection still lacks specific antiviral therapy, making the NS2B-NS3 protease an attractive target for drug development. However, allosteric inhibitors that bind to a site other than the...
6.
Suryo Rahmanto A, Blum C, Scalera C, Heidelberger J, Mesitov M, Horn-Ghetko D, et al.
Mol Cell
. 2023 Nov;
83(23):4272-4289.e10.
PMID: 37951215
Reactive aldehydes are produced by normal cellular metabolism or after alcohol consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are impaired. Their toxicity has been attributed to...
7.
Penner I, Dejung M, Freiwald A, Butter F, Chen J, Plachter B
Sci Data
. 2023 Aug;
10(1):517.
PMID: 37542058
Human cytomegalovirus (HCMV) is a pathogen of high medical relevance. Subviral Dense Bodies (DB) were developed as a vaccine candidate to ameliorate the severe consequences of HCMV infection. Development of...
8.
Kehrloesser S, Cast O, Elliott T, Ernst R, Machel A, Chen J, et al.
PNAS Nexus
. 2023 Apr;
2(4):pgad107.
PMID: 37091541
The ability to assign cellular origin to low-abundance secreted factors in extracellular vesicles (EVs) would greatly facilitate the analysis of paracrine-mediated signaling. Here, we report a method, named selective isolation...
9.
Kunert F, Metzner F, Jung J, Hopfler M, Woike S, Schall K, et al.
Sci Adv
. 2022 Dec;
8(49):eadd3189.
PMID: 36490333
The nucleosomal landscape of chromatin depends on the concerted action of chromatin remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene regulatory elements, which is proposed to...
10.
Jiang F, Liu K, Chen J, Cao Y, Chen W, Zhao W, et al.
Elife
. 2022 Nov;
11.
PMID: 36399125
Cardiovascular disease is the leading cause of death worldwide due to the inability of adult heart to regenerate after injury. -methyladenosine (mA) methylation catalyzed by the enzyme methyltransferase-like 3 (Mettl3)...