Felix F Schumacher
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Explore the profile of Felix F Schumacher including associated specialties, affiliations and a list of published articles.
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11
Citations
363
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Recent Articles
1.
Sela T, Manso M, Siegel M, Marban-Doran C, Ducret A, Niewohner J, et al.
Bioconjug Chem
. 2023 Nov;
34(11):2096-2111.
PMID: 37916986
Antisense-oligonucleotides (ASOs) are a promising drug modality for the treatment of neurological disorders, but the currently established route of administration intrathecal delivery is a major limitation to its broader clinical...
2.
Schumacher F, Nunes J, Maruani A, Chudasama V, Smith M, Chester K, et al.
Org Biomol Chem
. 2014 Aug;
12(37):7261-9.
PMID: 25103319
The advent of Adcetris™ and Kadcyla™, two recently FDA-approved antibody-drug conjugates (ADCs), in the clinic has had a major impact on the treatment of lymphoma and breast cancer patients, respectively,...
3.
Castaneda L, Maruani A, Schumacher F, Miranda E, Chudasama V, Chester K, et al.
Chem Commun (Camb)
. 2013 Aug;
49(74):8187-9.
PMID: 23929130
In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous...
4.
Schumacher F, Sanchania V, Tolner B, Wright Z, Ryan C, Smith M, et al.
Sci Rep
. 2013 Mar;
3:1525.
PMID: 23519366
A major obstacle to the efficient production of antibody conjugates for therapy and diagnosis is the non-ideal performance of commonly used chemical methods for the attachment of effector-molecules to the...
5.
Jones M, Strickland R, Schumacher F, Caddick S, Baker J, Gibson M, et al.
Chem Commun (Camb)
. 2012 Mar;
48(34):4064-6.
PMID: 22436767
The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide...
6.
Jones M, Strickland R, Schumacher F, Caddick S, Baker J, Gibson M, et al.
J Am Chem Soc
. 2011 Dec;
134(3):1847-52.
PMID: 22188166
A series of dibromomaleimides have been shown to be very efficacious at insertion into peptidic disulfide bonds. This conjugation proceeds with a stoichiometric balance of reagents in buffered solutions in...
7.
Chudasama V, Smith M, Schumacher F, Papaioannou D, Waksman G, Baker J, et al.
Chem Commun (Camb)
. 2011 Jul;
47(31):8781-3.
PMID: 21738916
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show...
8.
Ryan C, Smith M, Schumacher F, Grohmann D, Papaioannou D, Waksman G, et al.
Chem Commun (Camb)
. 2011 Apr;
47(19):5452-4.
PMID: 21465057
Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconjugates which are either stable or cleavable in an aqueous, thiol-mediated reducing environment. The application of this methodology to reversible protein...
9.
Nan R, Farabella I, Schumacher F, Miller A, Gor J, Martin A, et al.
J Mol Biol
. 2011 Mar;
408(4):714-35.
PMID: 21396937
The Tyr402His polymorphism of complement factor H (FH) with 20 short complement regulator (SCR) domains is associated with age-related macular degeneration (AMD). How FH contributes to disease pathology is not...
10.
Schumacher F, Nobles M, Ryan C, Smith M, Tinker A, Caddick S, et al.
Bioconjug Chem
. 2011 Jan;
22(2):132-6.
PMID: 21271715
The introduction of non-natural entities into proteins by chemical modification has numerous applications in fundamental biological science and for the development and manipulation of peptide and protein therapeutics. The reduction...