Felix Epie
Overview
Explore the profile of Felix Epie including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
26
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Recent Articles
1.
Zhang J, Chan A, Lippa B, Cross J, Liu C, Yin N, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(8):1670-1680.
PMID: 28302397
The emergence and spread of multidrug-resistant (MDR) Gram negative bacteria presents a serious threat for public health. Novel antimicrobials that could overcome the resistance problems are urgently needed. UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase...
2.
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Cross J, Zhang J, Yang Q, Mesleh M, Romero J, Wang B, et al.
ACS Med Chem Lett
. 2016 Apr;
7(4):374-8.
PMID: 27096044
The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class...
3.
Zhang J, Yang Q, Romero J, Cross J, Wang B, Poutsiaka K, et al.
ACS Med Chem Lett
. 2015 Oct;
6(10):1080-5.
PMID: 26487916
Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically validated target. Through physiochemical property optimization of a...
4.
Zhang J, Yang Q, Cross J, Romero J, Poutsiaka K, Epie F, et al.
J Med Chem
. 2015 Oct;
58(21):8503-12.
PMID: 26460684
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed....