Fang-Jen S Lee
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Explore the profile of Fang-Jen S Lee including associated specialties, affiliations and a list of published articles.
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36
Citations
583
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Recent Articles
1.
Lin S, Lin M, Liu T, Tsai Y, Tsai M, Lee F
Nat Commun
. 2023 Nov;
14(1):7859.
PMID: 38030597
Ligand-induced epidermal growth factor receptor (EGFR) endocytosis followed by endosomal EGFR signaling and lysosomal degradation plays important roles in controlling multiple biological processes. ADP-ribosylation factor (Arf)-like protein 4 A (Arl4A)...
2.
Lai C, Chiu W, Chen Y, Wu C, Lee F
Mol Biol Cell
. 2023 Aug;
34(11):ar112.
PMID: 37610835
Vesicular trafficking involving SNARE proteins play a crucial role in the delivery of cargo to the target membrane. Arf-like protein 1 (Arl1) is an important regulator of the endosomal -Golgi...
3.
Chen K, Hsu J, Lee F
J Cell Sci
. 2022 Aug;
135(18).
PMID: 36017701
AMP-activated protein kinase (AMPK) is a crucial cellular nutrient and energy sensor that maintains energy homeostasis. AMPK also governs cancer cell invasion and migration by regulating gene expression and activating...
4.
Lin M, Yu C, Lee F
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2207414119.
PMID: 35857868
The Arl4 small GTPases participate in a variety of cellular events, including cytoskeleton remodeling, vesicle trafficking, cell migration, and neuronal development. Whereas small GTPases are typically regulated by their GTPase...
5.
Wang Y, Chiu W, Chen Y, Cai P, Wu Y, Wu J, et al.
Cell Rep
. 2022 Mar;
38(12):110488.
PMID: 35320730
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR), which acts through various mechanisms to reduce ER stress. While the UPR has been...
6.
Lin S, Huang C, Wu T, Li C, Lee F
Mol Biol Cell
. 2020 Aug;
31(21):2348-2362.
PMID: 32755434
ADP-ribosylation factor (Arf)-like 4D (Arl4D), one of the Arf-like small GTPases, functions in the regulation of cell morphology, cell migration, and actin cytoskeleton remodeling. End-binding 1 (EB1) is a microtubule...
7.
Chen K, Chiang T, Yu C, Lee F
J Cell Sci
. 2020 Jan;
133(3).
PMID: 31932503
Cell migration requires the coordination of multiple signaling pathways involved in membrane dynamics and cytoskeletal rearrangement. The Arf-like small GTPase Arl4A has been shown to modulate actin cytoskeleton remodeling. However,...
8.
Sztul E, Chen P, Casanova J, Cherfils J, Dacks J, Lambright D, et al.
Mol Biol Cell
. 2019 May;
30(11):1249-1271.
PMID: 31084567
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its actions in cells. Studying a protein family in the aggregate yields additional...
9.
Chen Y, Wang I, Wang Y, Chiu W, Hu J, Chen W, et al.
Mol Biol Cell
. 2019 Feb;
30(8):1008-1019.
PMID: 30726160
The Arf and Rab/Ypt GTPases coordinately regulate membrane traffic and organelle structure by regulating vesicle formation and fusion. Ample evidence has indicated that proteins in these two families may function...
10.
Chiang T, Lin M, Tsai M, Chen C, Jang L, Lee F
Mol Biol Cell
. 2018 Nov;
30(1):69-81.
PMID: 30427759
Cell migration is a highly regulated event that is initiated by cell membrane protrusion and actin reorganization. Robo1, a single-pass transmembrane receptor, is crucial for neuronal guidance and cell migration....