Fabrice Lemaitre
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Explore the profile of Fabrice Lemaitre including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
1984
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0
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Recent Articles
1.
Ruggiu M, Guerin M, Corre B, Bardou M, Alonso R, Russo E, et al.
J Exp Med
. 2024 Feb;
221(4).
PMID: 38417020
Anti-PD-1 therapy targets intratumoral CD8+ T cells to promote clinical responses in cancer patients. Recent evidence suggests an additional activity in the periphery, but the underlying mechanism is unclear. Here,...
2.
Boulch M, Cazaux M, Cuffel A, Guerin M, Garcia Z, Alonso R, et al.
Nat Cancer
. 2023 May;
4(7):968-983.
PMID: 37248395
CD4 T cells and CD4 chimeric antigen receptor (CAR) T cells display highly variable antitumor activity in preclinical models and in patients; however, the mechanisms dictating how and when CD4...
3.
Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics
Corre B, El Janati Elidrissi Y, Duval J, Quilhot M, Lefebvre G, Ecomard S, et al.
iScience
. 2023 Feb;
26(2):106068.
PMID: 36824271
T cells become activated following one or multiple contacts with antigen-presenting cells. Calcium influx is a key signaling event elicited during these cellular interactions; however, it is unclear whether T ...
4.
Russo E, Lemaitre F, Corre B, Chikina A, Langa-Vives F, Bousso P
EMBO J
. 2022 Aug;
41(19):e111528.
PMID: 35997165
The regulation of cellular energy metabolism is central to most physiological and pathophysiological processes. However, most current methods have limited ability to functionally probe metabolic pathways in individual cells. Here,...
5.
Khazen R, Corre B, Garcia Z, Lemaitre F, Bachellier-Bassi S, dEnfert C, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(29):e2203855119.
PMID: 35858359
Neutrophils form cellular clusters or swarms in response to injury or pathogen intrusion. Yet, intracellular signaling events favoring this coordinated response remain to be fully characterized. Here, we show that...
6.
Bardou M, Postat J, Loaec C, Lemaitre F, Ronteix G, Garcia Z, et al.
EMBO J
. 2021 Jun;
40(15):e107176.
PMID: 34124789
Dendritic cell (DC) activation by viral RNA sensors such as TLR3 and MDA-5 is critical for initiating antiviral immunity. Optimal DC activation is promoted by type I interferon (IFN) signaling...
7.
Khazen R, Cazaux M, Lemaitre F, Corre B, Garcia Z, Bousso P
EMBO J
. 2021 Apr;
40(11):e106658.
PMID: 33855732
Cytotoxic T cells (CTLs) can eliminate tumor cells through the delivery of lethal hits, but the actual efficiency of this process in the tumor microenvironment is unclear. Here, we visualized...
8.
Boulch M, Cazaux M, Loe-Mie Y, Thibaut R, Corre B, Lemaitre F, et al.
Sci Immunol
. 2021 Mar;
6(57).
PMID: 33771887
Chimeric antigen receptor (CAR) T cell therapy relies on the activity of a large pool of tumor-targeting cytotoxic effectors. Whether CAR T cells act autonomously or require interactions with the...
9.
Grandjean C, Garcia Z, Lemaitre F, Breart B, Bousso P
Sci Adv
. 2021 Feb;
7(8).
PMID: 33608271
Anti-CD20 antibody (mAb) represents an effective strategy for the treatment of B cell malignancies, possibly involving complement activity, antibody-dependent cellular cytotoxicity and phagocytosis (ADP). While ADP by Kupffer cells deplete...
10.
Thibaut R, Bost P, Milo I, Cazaux M, Lemaitre F, Garcia Z, et al.
Nat Cancer
. 2020 Aug;
1(3):302-314.
PMID: 32803171
The cytokine IFN-γ produced by tumor-reactive T cells is a key effector molecule with pleiotropic effects during anti-tumor immune responses. While IFN-γ production is targeted at the immunological synapse, its...