Alpha 2.0
Login Register
» Authors » Fabiola Holetz

Fabiola Holetz

Explore the profile of Fabiola Holetz including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 101
Followers 0
Related Specialties
Biochemistry
Genetics
Top 10 Co-Authors
M Carolina Elias
Johanna Odenwald
Juliana Nunes Roson
Samuel Goldenberg
Hellida Marina Costa-Silva
Ariel M Silber
Pedro A F Galante
Camila Silva Goncalves
Loyze Paola Oliveira de Lima
Mark Carrington
Published In
Epigenetics Chromatin
J Biol Chem
Nucleic Acids Res
BMC Genomics
Front Cell Infect Microbiol
Affiliations
Soon will be listed here.
Recent Articles
1.
Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway
Gabiatti B, Freire E, Odenwald J, de Freitas Nascimento J, Holetz F, Carrington M, et al.
PLoS One . 2025 Mar; 20(3):e0315659. PMID: 40053537
The exon junction complex (EJC) is a key player in metazoan mRNA quality control and is placed upstream of the exon-exon junction after splicing. Its inner core is composed of...
2.
A short ncRNA modulates gene expression and affects stress response and parasite differentiation in
Quilles Jr J, Espada C, Orsine L, Defina T, Almeida L, Holetz F, et al.
Front Cell Infect Microbiol . 2025 Feb; 15:1513908. PMID: 39981380
The protozoan parasite spp. is a causative agent of leishmaniasis, a disease that affects millions of people in more than 80 countries worldwide. Apart from its medical relevance, this organism...
3.
A unique mRNA decapping complex in trypanosomes
Kramer S, Karolak N, Odenwald J, Gabiatti B, Castaneda Londono P, Zavrelova A, et al.
Nucleic Acids Res . 2023 Jun; 51(14):7520-7540. PMID: 37309887
Removal of the mRNA 5' cap primes transcripts for degradation and is central for regulating gene expression in eukaryotes. The canonical decapping enzyme Dcp2 is stringently controlled by assembly into...
4.
Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci
Lima A, Silva H, Poubel S, Roson J, de Lima L, Costa-Silva H, et al.
Epigenetics Chromatin . 2022 Jul; 15(1):25. PMID: 35794678
No abstract available.
5.
Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci
Lima A, Silva H, Poubel S, Roson J, de Lima L, Costa-Silva H, et al.
Epigenetics Chromatin . 2022 Jun; 15(1):22. PMID: 35650626
Background: Genomic organization and gene expression regulation in trypanosomes are remarkable because protein-coding genes are organized into codirectional gene clusters with unrelated functions. Moreover, there is no dedicated promoter for...
6.
Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi
Smircich P, Eastman G, Bispo S, Duhagon M, Guerra-Slompo E, Garat B, et al.
BMC Genomics . 2015 Jun; 16:443. PMID: 26054634
Background: Due to the absence of transcription initiation regulation of protein coding genes transcribed by RNA polymerase II, posttranscriptional regulation is responsible for the majority of gene expression changes in...
7.
Functional genomic characterization of mRNAs associated with TcPUF6, a pumilio-like protein from Trypanosoma cruzi
Dallagiovanna B, Correa A, Probst C, Holetz F, Smircich P, de Aguiar A, et al.
J Biol Chem . 2007 Dec; 283(13):8266-73. PMID: 18056709
Trypanosoma cruzi is the protozoan parasite that causes Chagas disease or American trypanosomiasis. Kinetoplastid parasites could be considered as model organisms for studying factors involved in posttranscriptional regulation because they...