Fabian Schuler
Overview
Explore the profile of Fabian Schuler including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
478
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0
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Recent Articles
1.
Karbon G, Schuler F, Braun V, Eichin F, Haschka M, Drach M, et al.
EMBO Rep
. 2024 May;
25(6):2743-2772.
PMID: 38806674
Interference with microtubule dynamics in mitosis activates the spindle assembly checkpoint (SAC) to prevent chromosome segregation errors. The SAC induces mitotic arrest by inhibiting the anaphase-promoting complex (APC) via the...
2.
Braun V, Karbon G, Schuler F, Schapfl M, Weiss J, Petermann P, et al.
Sci Adv
. 2024 Mar;
10(13):eadk0564.
PMID: 38552015
Deregulated centrosome numbers are frequently found in human cancer and can promote malignancies in model organisms. Current research aims to clarify if extra centrosomes are cause or consequence of malignant...
3.
Lohmuller M, Roeck B, Szabo T, Schapfl M, Pegka F, Herzog S, et al.
Mol Oncol
. 2022 Jun;
16(15):2771-2787.
PMID: 35673965
Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of under-replicated DNA or exogenous DNA damage....
4.
Huang A, Kremser L, Schuler F, Wilflingseder D, Lindner H, Geley S, et al.
Nucleic Acids Res
. 2019 Sep;
47(20):10754-10770.
PMID: 31535131
Centromeres are specialized chromosomal regions epigenetically defined by the presence of the histone H3 variant CENP-A. CENP-A is required for kinetochore formation which is essential for chromosome segregation during mitosis....
5.
Schuler F, Afreen S, Manzl C, Hacker G, Erlacher M, Villunger A
EMBO Rep
. 2019 Aug;
20(8):e47026.
PMID: 31379128
Checkpoint kinase 1 (CHK1) is critical for S-phase fidelity and preventing premature mitotic entry in the presence of DNA damage. Tumor cells have developed a strong dependence on CHK1 for...
6.
Schuler F, Weiss J, Lindner S, Lohmuller M, Herzog S, Spiegl S, et al.
Nat Commun
. 2017 Nov;
8(1):1697.
PMID: 29167438
Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression in response to DNA damage. Despite its essential function, CHK1 has been identified...
7.
Sladky V, Schuler F, Fava L, Villunger A
J Cell Sci
. 2017 Nov;
130(22):3779-3787.
PMID: 29142064
The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-induced death domain protein 1 (PIDD1), the bipartite linker protein CRADD (also known as RAIDD)...
8.
Gulen M, Koch U, Haag S, Schuler F, Apetoh L, Villunger A, et al.
Nat Commun
. 2017 Sep;
8(1):427.
PMID: 28874664
Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway,...
9.
Lindner S, Lohmuller M, Kotkamp B, Schuler F, Knust Z, Villunger A, et al.
EMBO Rep
. 2017 Jul;
18(9):1604-1617.
PMID: 28705801
Precursor B lymphocytes expand upon expression of a pre-B cell receptor (pre-BCR), but then transit into a resting state in which immunoglobulin light chain gene recombination is initiated. This bi-phasic...
10.
Fava L, Schuler F, Sladky V, Haschka M, Soratroi C, Eiterer L, et al.
Genes Dev
. 2017 Jan;
31(1):34-45.
PMID: 28130345
Centrosomes, the main microtubule-organizing centers in animal cells, are replicated exactly once during the cell division cycle to form the poles of the mitotic spindle. Supernumerary centrosomes can lead to...