Fabian Morales-Polanco
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Explore the profile of Fabian Morales-Polanco including associated specialties, affiliations and a list of published articles.
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9
Citations
149
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Recent Articles
1.
Gallicchio L, Matias N, Morales-Polanco F, Nava I, Stern S, Zeng Y, et al.
Genes Dev
. 2024 Aug;
38(13-14):655-674.
PMID: 39111825
Alternative cleavage and polyadenylation (APA) often results in production of mRNA isoforms with either longer or shorter 3' UTRs from the same genetic locus, potentially impacting mRNA translation, localization, and...
2.
Gallicchio L, Matias N, Morales-Polanco F, Nava I, Stern S, Zeng Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38562704
Alternative Cleavage and Polyadenylation (APA) often results in production of mRNA isoforms with either longer or shorter 3'UTRs from the same genetic locus, potentially impacting mRNA translation, localization and stability....
3.
Solari C, Martinez M, Fernandez J, Bates C, Cueto G, Valacco M, et al.
iScience
. 2024 Jan;
27(1):108727.
PMID: 38235324
The quiescent state is the prevalent mode of cellular life in most cells. is a useful model for studying the molecular basis of the cell cycle, quiescence, and aging. Previous...
4.
Betancourt Moreira K, Collier M, Leitner A, Li K, Lachapel I, McCarthy F, et al.
Mol Cell
. 2023 Aug;
83(17):3123-3139.e8.
PMID: 37625406
How the essential eukaryotic chaperonin TRiC/CCT assembles from eight distinct subunits into a unique double-ring architecture remains undefined. We show TRiC assembly involves a hierarchical pathway that segregates subunits with...
5.
Sontag E, Morales-Polanco F, Chen J, McDermott G, Dolan P, Gestaut D, et al.
Nat Cell Biol
. 2023 Apr;
25(5):699-713.
PMID: 37081164
Effective protein quality control (PQC), essential for cellular health, relies on spatial sequestration of misfolded proteins into defined inclusions. Here we reveal the coordination of nuclear and cytoplasmic spatial PQC....
6.
Morales-Polanco F, Lee J, Barbosa N, Frydman J
Annu Rev Biomed Data Sci
. 2022 Apr;
5:67-94.
PMID: 35472290
The formation of protein complexes is crucial to most biological functions. The cellular mechanisms governing protein complex biogenesis are not yet well understood, but some principles of cotranslational and posttranslational...
7.
Stein K, Morales-Polanco F, van der Lienden J, Rainbolt T, Frydman J
Nature
. 2022 Jan;
601(7894):637-642.
PMID: 35046576
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-related protein misfolding diseases. Yet, how ageing impairs proteostasis remains unclear. As nascent polypeptides represent a substantial burden...
8.
Morales-Polanco F, Bates C, Lui J, Casson J, Solari C, Pizzinga M, et al.
iScience
. 2021 Feb;
24(2):102069.
PMID: 33554071
Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and glycolytic enzymes are among the most abundant proteins in cells. Their expression at such levels provides a particular...
9.
Pizzinga M, Bates C, Lui J, Forte G, Morales-Polanco F, Linney E, et al.
J Cell Biol
. 2019 Mar;
218(5):1564-1581.
PMID: 30877141
mRNA localization serves key functions in localized protein production, making it critical that the translation machinery itself is present at these locations. Here we show that translation factor mRNAs are...