Fabian Dey
Overview
Explore the profile of Fabian Dey including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
203
Followers
0
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Recent Articles
1.
Waibl F, Casagrande F, Dey F, Riniker S
J Chem Inf Model
. 2024 Oct;
64(20):7938-7948.
PMID: 39405498
Macrocycles are a promising class of compounds as therapeutics for difficult drug targets due to a favorable combination of properties: They often exhibit improved binding affinity compared to their linear...
2.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jul;
631(8022):E17.
PMID: 38992182
No abstract available.
3.
Pahil K, Gilman M, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, et al.
Nature
. 2024 Jul;
631(8022):E18.
PMID: 38992181
No abstract available.
4.
Pahil K, Gilman M, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, et al.
Nature
. 2024 Jan;
625(7996):E27.
PMID: 38200318
No abstract available.
5.
Pahil K, Gilman M, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, et al.
Nature
. 2024 Jan;
625(7995):572-577.
PMID: 38172635
Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks the entry of most antibiotics. The impenetrable nature of the outer...
6.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jan;
625(7995):566-571.
PMID: 38172634
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options. No new antibiotic chemical class with activity against A. baumannii has reached patients in over...
7.
Hu Y, Shi H, Zhou M, Ren Q, Zhu W, Zhang W, et al.
J Med Chem
. 2020 Aug;
63(17):9623-9649.
PMID: 32787097
The rise of multidrug resistant (MDR) Gram-negative (GN) pathogens and the decline of available antibiotics that can effectively treat these severe infections are a major threat to modern medicine. Developing...
8.
Lin X, Shi H, Zhang W, Qiu Z, Zhou Z, Dey F, et al.
J Med Chem
. 2019 Nov;
62(22):10352-10361.
PMID: 31689116
Described herein is a new approach to mitigate CYP3A4 induction. In this unconventional approach, a fine-tuning of the dihedral angle between the C4 phenyl and the dihydropyrimidine core of the...
9.
Hwang H, Dey F, Petrey D, Honig B
Proc Natl Acad Sci U S A
. 2017 Dec;
114(52):13685-13690.
PMID: 29229851
We report a template-based method, LT-scanner, which scans the human proteome using protein structural alignment to identify proteins that are likely to bind ligands that are present in experimentally determined...
10.
Schoop A, Dey F
Drug Discov Today Technol
. 2016 Jan;
17:9-15.
PMID: 26724331
In the lead discovery process residence time has become an important parameter for the identification and characterization of the most efficacious compounds in vivo. To enable the success of compound...