F M Belpaire
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Explore the profile of F M Belpaire including associated specialties, affiliations and a list of published articles.
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Articles
113
Citations
417
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Recent Articles
1.
Van Sassenbroeck D, De Paepe P, Belpaire F, Rosseel M, Martens P, Boon P, et al.
J Pharm Pharmacol
. 2002 Jan;
53(12):1687-96.
PMID: 11804399
In view of the potential interest in an objective parameter for the depth of coma in intoxications with the recreational drug gamma-hydroxybutyrate (GHB), we have studied the relationship between the...
2.
De Paepe P, Van Sassenbroeck D, Belpaire F, Buylaert W
Crit Care Med
. 2001 May;
29(5):997-9.
PMID: 11378611
Objective: Hypovolemia has been shown to decrease the dose requirement for propofol. This increased effect has been explained partially by an increased end organ sensitivity to the anesthetic effect of...
3.
Hemeryck A, De Vriendt C, Belpaire F
Drug Metab Dispos
. 2001 Apr;
29(5):656-63.
PMID: 11302931
This study in human liver microsomes was undertaken to establish whether paroxetine stereoselectively inhibits the oxidative metabolism of metoprolol in vitro, and whether the in vivo observed magnitude of the...
4.
De Vriendt C, Van Sassenbroeck D, Rosseel M, van de Velde E, Verstraete A, Vander Heyden Y, et al.
J Chromatogr B Biomed Sci Appl
. 2001 Mar;
752(1):85-90.
PMID: 11254201
A method for the determination of gamma-hydroxybutyric acid (GHB) in rat plasma was developed using solid-phase extraction (SPE) and high-performance liquid chromatography (HPLC) with UV detection. GHB was isolated from...
5.
De Letter E, De Paepe P, Clauwaert K, Belpaire F, Lambert W, Van Bocxlaer J, et al.
Int J Legal Med
. 2001 Feb;
114(1-2):29-35.
PMID: 11197624
As drug instability and redistribution are factors known to affect the interpretation of post-mortem blood levels, we questioned whether post-mortem vitreous humour concentrations could be useful as predictors for the...
6.
De Paepe P, Belpaire F, Rosseel M, Van Hoey G, Boon P, Buylaert W
Anesthesiology
. 2001 Jan;
93(6):1482-90.
PMID: 11149444
Background: Hypovolemia decreases the dose requirement for anesthetics, but no data are available for propofol. As it is impossible to study this in patients, a rat model was used in...
7.
Hemeryck A, De Vriendt C, Belpaire F
J Clin Psychopharmacol
. 2000 Aug;
20(4):428-34.
PMID: 10917404
Propafenone is mainly metabolized by CYP2D6 to form 5-hydroxypropafenone (5-OHP) and to a minor extent by CYP1A2 and CYP3A4 to form N-depropylpropafenone (N-DPP). The in vitro inhibitory effect of selective...
8.
Hemeryck A, Lefebvre R, De Vriendt C, Belpaire F
Clin Pharmacol Ther
. 2000 Mar;
67(3):283-91.
PMID: 10741632
Objective: To investigate the effect of multiple-dose paroxetine intake on the stereoselective pharmacokinetics and the pharmacodynamics of metoprolol. Methods: We conducted an open trial with two sessions in eight healthy...
9.
Pan L, Belpaire F
Eur J Clin Pharmacol
. 1999 Dec;
55(8):599-604.
PMID: 10541779
Objective: To investigate in vitro which CYP isoforms (CYP1A2, CYP2D6 and CYP3A4) are involved in the biotransformation of haloperidol (HAL) and reduced haloperidol (RHAL). Methods: The biotransformation of HAL and...
10.
Pan L, Vander Stichele R, Rosseel M, Berlo J, De Schepper N, Belpaire F
Ther Drug Monit
. 1999 Oct;
21(5):489-97.
PMID: 10519444
The effects of smoking, CYP2D6 genotype, and concomitant use of enzyme inducers or inhibitors on the steady state plasma concentrations of haloperidol (HAL) and reduced haloperidol (RHAL) were evaluated in...