F L Moolten
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Explore the profile of F L Moolten including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
800
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Recent Articles
1.
Fareed M, Moolten F
Gene Ther
. 2002 Jun;
9(14):955-62.
PMID: 12085244
Stem cells and their progeny constitute a potential resource for replacing damaged tissues or supplying missing functions, but also pose a threat of aberrant behavior, including neoplastic growth or immunopathology....
2.
Moolten F, Vonderhaar B, Mroz P
Hum Gene Ther
. 1996 Jun;
7(10):1197-204.
PMID: 8793544
Drug sensitivity ("suicide") genes can sensitize cancer cells to chemotherapy, but therapeutic use of these genes is limited by difficulties in delivering them to all areas of established cancers. An...
3.
Tamiya T, Ono Y, Wei M, Mroz P, Moolten F, Chiocca E
Cancer Gene Ther
. 1996 May;
3(3):155-62.
PMID: 8725879
Genes that encode enzymes that convert inactive "prodrugs" into anticancer metabolites may be therapeutically useful against brain tumors. Unlike other genes tested to date in brain tumor models, the Escherichia...
4.
5.
Krepinsky J, Whitfield D, Douglas S, Lupescu N, Pulleyblank D, Moolten F
Methods Enzymol
. 1994 Jan;
247:144-53.
PMID: 7898350
No abstract available.
6.
Freeman S, Abboud C, Whartenby K, Packman C, Koeplin D, Moolten F, et al.
Cancer Res
. 1993 Nov;
53(21):5274-83.
PMID: 8221662
Tumor cells expressing the herpes simplex virus thymidine kinase (HSV-TK) gene are sensitive to the drug ganciclovir (GCV). We demonstrate here that HSV-TK-positive cells exposed to GCV were lethal to...
7.
Mroz P, Moolten F
Hum Gene Ther
. 1993 Oct;
4(5):589-95.
PMID: 8280797
"Suicide genes" encoding exceptional sensitivity to chemotherapeutic agents can potentially improve the selectivity of cancer therapy. As a component of a retroviral gene therapy vector, a suicide gene might also...
8.
Takamiya Y, Short M, Moolten F, Fleet C, Mineta T, Breakefield X, et al.
J Neurosurg
. 1993 Jul;
79(1):104-10.
PMID: 8391069
Recent research using rodent models of central nervous system gliomas indicates that a combination of gene transfer and drug treatment may be successful in killing tumor cells. In the present...
9.
Takamiya Y, Short M, Ezzeddine Z, Moolten F, Breakefield X, Martuza R
J Neurosci Res
. 1992 Nov;
33(3):493-503.
PMID: 1335091
Tumor cells infected with a retrovirus vector (VIK) containing the herpes simplex virus thymidine kinase (HSV-TK) gene can be selectively killed by treatment with nucleoside analogues, such as ganciclovir. To...
10.
Moolten F, Cupples L
Hum Gene Ther
. 1992 Oct;
3(5):479-86.
PMID: 1420447
Theoretical estimates of the risk of cancer resulting from accidental insertion of retroviral gene therapy vectors into oncogenically vulnerable genomic sites may prove an important supplement to experimentally derived data...