F Essmann
Overview
Explore the profile of F Essmann including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
545
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0
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Recent Articles
1.
Gillissen B, Richter A, Overkamp T, Essmann F, Hemmati P, Preissner R, et al.
Cell Death Dis
. 2013 May;
4:e643.
PMID: 23703388
TRAIL is a promising anticancer agent, capable of inducing apoptosis in a wide range of treatment-resistant tumor cells. In 'type II' cells, the death signal triggered by TRAIL requires amplification...
2.
Keil E, Hocker R, Schuster M, Essmann F, Ueffing N, Hoffman B, et al.
Cell Death Differ
. 2012 Oct;
20(2):321-32.
PMID: 23059785
Autophagy is a lysosomal degradation pathway important for cellular homeostasis, mammalian development, cancer and immunity. Many molecular components of autophagy have been identified, but little is known about regulatory mechanisms...
3.
Konantz M, Andre M, Ebinger M, Grauer M, Wang H, Grzywna S, et al.
Leukemia
. 2012 Jul;
27(1):56-65.
PMID: 22828445
The transcriptional regulator ecotropic viral integration site-1 (EVI-1) has mainly been studied for its role in myeloid malignancies, in which high EVI-1 levels are associated with particularly aggressive disease. The...
4.
Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen B, et al.
Cell Death Differ
. 2011 Jan;
18(7):1130-9.
PMID: 21233848
During apoptosis Bcl-2 proteins control permeabilization of the mitochondrial outer membrane leading to the release of cytochrome c. Essential gatekeepers for cytochrome c release are the proapoptotic multidomain proteins, Bax,...
5.
Schmidt S, Schneider L, Essmann F, Cirstea I, Kuck F, Kletke A, et al.
Oncogene
. 2010 Aug;
29(46):6184-92.
PMID: 20729911
Microtubule-interfering cancer drugs such as paclitaxel (PTX) often cause chemoresistance and severe side effects, including neurotoxicity. To explore potentially novel antineoplastic molecular targets, we investigated the cellular response of breast...
6.
Werdehausen R, Fazeli S, Braun S, Hermanns H, Essmann F, Hollmann M, et al.
Br J Anaesth
. 2009 Aug;
103(5):711-8.
PMID: 19700777
Background: Local anaesthetics are known to induce apoptosis in clinically relevant concentrations. Hitherto, it is unknown what determines the apoptotic potency of local anaesthetics. Therefore, we compared apoptosis induction by...
7.
Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Janicke R
Cell Death Differ
. 2009 Feb;
16(6):869-78.
PMID: 19229248
Pifithrin-alpha (PFT-alpha) was shown to specifically block transcriptional activity of the tumor suppressor p53 and was therefore proposed to be useful in preventing the severe side effects often associated with...
8.
Hassan M, Alaoui A, Feyen O, Mirmohammadsadegh A, Essmann F, Tannapfel A, et al.
Oncogene
. 2008 Apr;
27(33):4557-68.
PMID: 18408751
The molecular causes for resistance of melanoma to apoptosis are currently only partly understood. In the present study, we examined gene transfer and expression of the proapoptotic BH3-only protein Noxa...
9.
Neise D, Graupner V, Gillissen B, Daniel P, Schulze-Osthoff K, Janicke R, et al.
Oncogene
. 2007 Aug;
27(10):1387-96.
PMID: 17724463
Among the members of the Bcl-2 family, the multidomain proteins Bax and Bak are crucial for the activation of mitochondria. However, it is still unclear whether they act in a...
10.
Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Schulze-Osthoff K, et al.
Oncogene
. 2007 Jun;
27(1):116-25.
PMID: 17599038
Regulators of the mitotic spindle apparatus are attractive cellular targets for antitumor therapy. The centrosomal protein transforming acidic coiled coil (TACC) 3 is required for spindle assembly and proper chromosome...